5DA3
Crystal structure of PTK6 Kinase domain with inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | ASP312 |
| A | ARG316 |
| A | HIS345 |
| A | TRP353 |
| A | HOH681 |
| A | HOH688 |
| A | HOH759 |
| A | HOH762 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ALA334 |
| A | ILE337 |
| A | GLU339 |
| A | TYR342 |
| A | HOH719 |
| A | ARG311 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue 58V A 503 |
| Chain | Residue |
| A | ARG195 |
| A | LEU197 |
| A | ALA217 |
| A | LYS219 |
| A | LEU248 |
| A | THR264 |
| A | GLU265 |
| A | MET267 |
| A | ALA268 |
| A | GLY270 |
| A | LEU319 |
| A | ASP330 |
| A | GLN430 |
| A | HOH609 |
| A | HOH622 |
| A | HOH753 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGYFGEVFeGlwkdrvq...........VAIK |
| Chain | Residue | Details |
| A | LEU197-LYS219 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YIHrDLAARNILV |
| Chain | Residue | Details |
| A | TYR308-VAL320 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27480927","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27993680","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"12121988","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
