5D10

Kinase domain of cSrc in complex with RL236

Summary for 5D10

• Entry DOI: 10.2210/pdb5d10/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide (3 entities in total)
• Functional Keywords: kinase inhibitor, drug resistance, transferase
• Biological source: Gallus gallus (Chicken)
• Cellular location: Cell membrane : P00523
• Total number of polymer chains: 2
• Total formula weight: 66414.59

Authors

Becker, C.,Mayer-Wrangowski, S.C.,Julian, E.,Rauh, D. (deposition date: 2015-08-03, release date: 2015-09-02, Last modification date: 2024-01-10)

• Primary citation: Engel, J.,Richters, A.,Getlik, M.,Tomassi, S.,Keul, M.,Termathe, M.,Lategahn, J.,Becker, C.,Mayer-Wrangowski, S.,Grutter, C.,Uhlenbrock, N.,Krull, J.,Schaumann, N.,Eppmann, S.,Kibies, P.,Hoffgaard, F.,Heil, J.,Menninger, S.,Ortiz-Cuaran, S.,Heuckmann, J.M.,Tinnefeld, V.,Zahedi, R.P.,Sos, M.L.,Schultz-Fademrecht, C.,Thomas, R.K.,Kast, S.M.,Rauh, D.; Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.; J.Med.Chem., 58:6844-6863, 2015; PubMed: 26275028; DOI: 10.1021/acs.jmedchem.5b01082

Experimental method

X-RAY DIFFRACTION (2.7 Å)