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5CF4

CRYSTAL STRUCTURE OF JANUS KINASE 2 IN COMPLEX WITH N,N-DICYCLOPROPYL-10-ETHYL-7-[(3-METHOXYPROPYL)AMINO] -3-METHYL-3,5,8,10-TETRAAZATRICYCLO[7.3.0.0,6] DODECA-1(9),2(6),4,7,11-PENTAENE-11-CARBOXAMIDE

Summary for 5CF4
Entry DOI10.2210/pdb5cf4/pdb
Related5CF5 5CF6 5CF8
DescriptorTyrosine-protein kinase JAK2, N,N-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (3 entities in total)
Functional Keywordskinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationEndomembrane system ; Peripheral membrane protein : O60674
Total number of polymer chains2
Total formula weight76554.97
Authors
Sack, J.S. (deposition date: 2015-07-08, release date: 2015-08-26, Last modification date: 2017-11-22)
Primary citationHart, A.C.,Schroeder, G.M.,Wan, H.,Grebinski, J.,Inghrim, J.,Kempson, J.,Guo, J.,Pitts, W.J.,Tokarski, J.S.,Sack, J.S.,Khan, J.A.,Lippy, J.,Lorenzi, M.V.,You, D.,McDevitt, T.,Vuppugalla, R.,Zhang, Y.,Lombardo, L.J.,Trainor, G.L.,Purandare, A.V.
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.
Acs Med.Chem.Lett., 6:845-849, 2015
Cited by
PubMed: 26288682
DOI: 10.1021/acsmedchemlett.5b00225
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.38 Å)
Structure validation

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