5CEN

Crystal structure of DLK (kinase domain)

Summary for 5CEN

Related5CEO 5CEP 5CEQ
DescriptorMitogen-activated protein kinase kinase kinase 12 (2 entities in total)
Functional Keywordskinase, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  Q12852
Total number of polymer chains1
Total molecular weight34018.03
Authors
HARRIS, S.F.,YIN, J. (deposition date: 2015-07-07, release date: 2015-10-14, Last modification date: 2015-11-04)
Primary citation
Patel, S.,Harris, S.F.,Gibbons, P.,Deshmukh, G.,Gustafson, A.,Kellar, T.,Lin, H.,Liu, X.,Liu, Y.,Liu, Y.,Ma, C.,Scearce-Levie, K.,Ghosh, A.S.,Shin, Y.G.,Solanoy, H.,Wang, J.,Wang, B.,Yin, J.,Siu, M.,Lewcock, J.W.
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).
J.Med.Chem., 58:8182-8199, 2015
PubMed: 26431428 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.5b01072
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22930 3.2% 3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-10-28