5D12

Kinase domain of cSrc in complex with RL40

Summary for 5D12

Entry DOI	10.2210/pdb5d12/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide (2 entities in total)
Functional Keywords	kinase inhibitor, drug resistance, transferase
Biological source	Gallus gallus (Chicken) More
Total number of polymer chains	2
Total formula weight	66258.36
Authors	Becker, C.,Richters, A.,Engel, J.,Rauh, D. (deposition date: 2015-08-03, release date: 2015-09-09, Last modification date: 2019-02-20)
Primary citation	Engel, J.,Richters, A.,Getlik, M.,Tomassi, S.,Keul, M.,Termathe, M.,Lategahn, J.,Becker, C.,Mayer-Wrangowski, S.,Grutter, C.,Uhlenbrock, N.,Krull, J.,Schaumann, N.,Eppmann, S.,Kibies, P.,Hoffgaard, F.,Heil, J.,Menninger, S.,Ortiz-Cuaran, S.,Heuckmann, J.M.,Tinnefeld, V.,Zahedi, R.P.,Sos, M.L.,Schultz-Fademrecht, C.,Thomas, R.K.,Kast, S.M.,Rauh, D. Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J.Med.Chem., 58:6844-6863, 2015 Cited by PubMed: 26275028 DOI: 10.1021/acs.jmedchem.5b01082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation