5D12
Kinase domain of cSrc in complex with RL40
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32772.8 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | C, D (A, B) | N-[2-phenyl-4-(1H-pyrazol-3-ylamino)quinazolin-7-yl]prop-2-enamide | non-polymer | 356.4 | 2 | Chemie (G97) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Met 338 | Thr 338 | engineered mutation |
| Cys 345 | Ser 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65545.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 712.8 | |
| All* | Total formula weight | 66258.4 |
