Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue G97 A 601 |
| Chain | Residue |
| A | LEU273 |
| A | GLY274 |
| A | MET338 |
| A | GLU339 |
| A | TYR340 |
| A | MET341 |
| A | SER342 |
| A | GLY344 |
| A | LEU393 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue G97 B 601 |
| Chain | Residue |
| B | LEU273 |
| B | ALA293 |
| B | GLU339 |
| B | TYR340 |
| B | MET341 |
| B | GLY344 |
| B | LEU393 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide ARG B 264 and PRO B 333 |
| Chain | Residue |
| A | ALA259 |
| A | ASN287 |
| B | ILE262 |
| B | PRO263 |
| B | GLU265 |
| B | SER266 |
| B | LEU267 |
| B | LEU297 |
| B | VAL329 |
| B | GLU331 |
| B | GLU332 |
| B | ILE334 |
| B | TYR335 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide ALA B 327 and VAL B 337 |
| Chain | Residue |
| B | TRP260 |
| B | TRP286 |
| B | LEU325 |
| B | TYR326 |
| B | VAL328 |
| B | ILE336 |
| B | MET338 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide CYS B 345 and ASP B 348 |
| Chain | Residue |
| B | GLY344 |
| B | LEU346 |
| B | LEU347 |
| B | PHE349 |
| B | LEU350 |
| B | GLY352 |
| B | ALA390 |
| B | ILE392 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide CYS B 345 and ASP B 348 |
| Chain | Residue |
| B | GLY344 |
| B | LEU346 |
| B | LEU347 |
| B | PHE349 |
| B | LEU350 |
| B | GLY352 |
| B | ALA390 |
| B | ILE392 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK |
| Chain | Residue | Details |
| A | LEU273-LYS295 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV |
| Chain | Residue | Details |
| A | TYR382-VAL394 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"8856081","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"19948721","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"2420005","evidenceCode":"ECO:0000269"}]} |
