5CY3

SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor

Summary for 5CY3

• Entry DOI: 10.2210/pdb5cy3/pdb
• Related: 5CXH
• Descriptor: Tyrosine-protein kinase SYK, (5R)-5-[(1R)-1-{[6-(1-methyl-1H-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one (3 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 1
• Total formula weight: 34200.32

Authors

Lee, C.C. (deposition date: 2015-07-30, release date: 2015-09-23, Last modification date: 2024-03-06)

• Primary citation: Thoma, G.,Veenstra, S.,Strang, R.,Blanz, J.,Vangrevelinghe, E.,Berghausen, J.,Lee, C.C.,Zerwes, H.G.; Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.; Bioorg.Med.Chem.Lett., 25:4642-4647, 2015; PubMed: 26320624; DOI: 10.1016/j.bmcl.2015.08.037

Experimental method

X-RAY DIFFRACTION (1.76 Å)