5CY3

SYK catalytic domain complexed with a potent and orally bioavailable benzisothiazole inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	291	33855.9	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A	(5R)-5-[(1R)-1-{[6-(1-methyl-1H-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one	non-polymer		344.4	1	Chemie (55Y)
3		water	water		18.0	193	Chemie (HOH)

Sequence modifications

A: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	initiating methionine
Ala 354	-	expression tag
Leu 355	-	expression tag
Thr 467	Lys 467	engineered mutation
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33855.9
Non-Polymers*	Number of molecules	1
	Total formula weight	344.4
All*	Total formula weight	34200.3

*Water molecules are not included.