5CXH
SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor
Summary for 5CXH
Entry DOI | 10.2210/pdb5cxh/pdb |
Related | 4RX7 4RX8 4RX9 |
Descriptor | Tyrosine-protein kinase SYK, (4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one (3 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 34069.23 |
Authors | Lee, C.C. (deposition date: 2015-07-29, release date: 2015-09-23, Last modification date: 2024-03-06) |
Primary citation | Thoma, G.,Veenstra, S.,Strang, R.,Blanz, J.,Vangrevelinghe, E.,Berghausen, J.,Lee, C.C.,Zerwes, H.G. Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25:4642-4647, 2015 Cited by PubMed: 26320624DOI: 10.1016/j.bmcl.2015.08.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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