5CXH

SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	289	33669.8	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A	(4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one	non-polymer		399.5	1	Chemie (55M)
3		water	water		18.0	214	Chemie (HOH)

Sequence modifications

A: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	initiating methionine
Ala 354	-	expression tag
Leu 355	-	expression tag
Thr 467	Lys 467	engineered mutation
His 636	-	expression tag
His 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33669.8
Non-Polymers*	Number of molecules	1
	Total formula weight	399.5
All*	Total formula weight	34069.2

*Water molecules are not included.