5CXH

SYK catalytic domain complexed with a potent orally bioavailable thiazole inhibitor

Summary for 5CXH

Entry DOI	10.2210/pdb5cxh/pdb
Related	4RX7 4RX8 4RX9
Descriptor	Tyrosine-protein kinase SYK, (4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one (3 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane : P43405
Total number of polymer chains	1
Total formula weight	34069.23
Authors	Lee, C.C. (deposition date: 2015-07-29, release date: 2015-09-23, Last modification date: 2024-03-06)
Primary citation	Thoma, G.,Veenstra, S.,Strang, R.,Blanz, J.,Vangrevelinghe, E.,Berghausen, J.,Lee, C.C.,Zerwes, H.G. Orally bioavailable Syk inhibitors with activity in a rat PK/PD model. Bioorg.Med.Chem.Lett., 25:4642-4647, 2015 Cited by PubMed: 26320624 DOI: 10.1016/j.bmcl.2015.08.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation