5DG5

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157

Summary for 5DG5

• Entry DOI: 10.2210/pdb5dg5/pdb
• Descriptor: Hepatocyte growth factor receptor, N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide (3 entities in total)
• Functional Keywords: tyrosine kinase domain, hepatocyte growth factor receptor c-met, c-met, altiratinib analog, dp-4157, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 2
• Total formula weight: 72996.19

Authors

Smith, B.D.,Kaufman, M.D.,Leary, C.B.,Turner, B.A.,Wise, S.A.,Ahn, Y.M.,Booth, R.J.,Caldwell, T.M.,Ensinger, C.L.,Hood, M.M.,Lu, W.-P.,Patt, T.W.,Patt, W.C.,Rutkoski, T.J.,Samarakoon, T.,Telikepalli, H.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Chun, L.,Stewart, L.J.,Clare, M.,Flynn, D.L. (deposition date: 2015-08-27, release date: 2016-08-31, Last modification date: 2023-09-27)

• Primary citation: Smith, B.D.,Kaufman, M.D.,Leary, C.B.,Turner, B.A.,Wise, S.C.,Ahn, Y.M.,Booth, R.J.,Caldwell, T.M.,Ensinger, C.L.,Hood, M.M.,Lu, W.P.,Patt, T.W.,Patt, W.C.,Rutkoski, T.J.,Samarakoon, T.,Telikepalli, H.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Chun, L.,Stewart, L.J.,Clare, M.,Flynn, D.L.; Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.; Mol.Cancer Ther., 14:2023-2034, 2015; PubMed: 26285778; DOI: 10.1158/1535-7163.MCT-14-1105

Experimental method

X-RAY DIFFRACTION (2.6 Å)