5DG5

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hepatocyte growth factor receptor	polymer	318	35990.6	2	UniProt (P08581) Pfam (PF07714)	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
2	C, D (A, B)	N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide	non-polymer		507.5	2	Chemie (5B4)
3	E, F (A, B)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A, B: 1038 - 1346 (UniProt: P08581)

PDB	External Database	Details
Met 1029	-	initiating methionine
Gly 1030	-	expression tag
His 1031	-	expression tag
His 1032	-	expression tag
His 1033	-	expression tag
His 1034	-	expression tag
His 1035	-	expression tag
His 1036	-	expression tag
Met 1037	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71981.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.9
All*	Total formula weight	72996.2

*Water molecules are not included.