5DG5
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Hepatocyte growth factor receptor | polymer | 318 | 35990.6 | 2 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
2 | A, B | N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide | non-polymer | 507.5 | 2 | Chemie (5B4) | |||
3 | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A, B: 1038 - 1346 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1029 | - | initiating methionine |
Gly 1030 | - | expression tag |
His 1031 | - | expression tag |
His 1032 | - | expression tag |
His 1033 | - | expression tag |
His 1034 | - | expression tag |
His 1035 | - | expression tag |
His 1036 | - | expression tag |
Met 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71981.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1014.9 | |
All* | Total formula weight | 72996.2 |