PDB: 220 件ウェブページステータス検索Chemie searchBIRD

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5OJN	Sirtuin 4 from Xenopus tropicalis in complex with thioacetyl-ADP-ribose 分子名称: NAD-dependent protein deacylase, ZINC ION, thioacetyl-ADP-ribose 著者 Pannek, M, Steegborn, C. 登録日 2017-07-22 公開日 2017-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun, 8, 2017
5OL0	Structure of Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSIR2rp1) in complex with acetylated p53 peptide 分子名称: Cellular tumor antigen p53, Putative silent information regulator 2,Putative silent information regulator 2, ZINC ION 著者 Ronin, C, Ciesielski, F, Ciapetti, P. 登録日 2017-07-26 公開日 2018-02-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design. PLoS ONE, 13, 2018
5OJ7	Sirtuin 4 orthologue from Xenopus Tropicalis in complex with ADP-ribose 分子名称: 1,2-ETHANEDIOL, GLYCEROL, NAD-dependent protein deacylase, ... 著者 Pannek, M, Steegborn, C. 登録日 2017-07-20 公開日 2017-11-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun, 8, 2017
5OJO	Sirtuin 5 from Danio rerio in complex with 3-hydroxy-3-methylglutaryl-CPS1 peptide 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Carbamoyl-phosphate synthase [ammonia], ... 著者 Pannek, M, Steegborn, C. 登録日 2017-07-22 公開日 2017-11-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. Nat Commun, 8, 2017
6RXM	Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16-Acetyl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6ISO	Human SIRT3 Recognizing H3K4cr 分子名称: (2E)-BUT-2-ENAL, ARG-THR-LYS-GLN-THR-ALA-ARG, GLYCEROL, ... 著者 Wang, Y, Hao, Q. 登録日 2018-11-17 公開日 2019-01-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Elife, 3, 2014
6RXQ	Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16Cr-2'OH-ADPr peptide intermediate after soaking 分子名称: Histone H4, NAD-dependent protein deacylase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-4-[(~{E})-but-2-enoxy]-3,5-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXK	Crystal structure of CobB wt in complex with H4K16-Butyryl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXS	Crystal structure of CobB Ac3(A76G,Y92A, I131L, V187Y) in complex with H4K16-Acetyl peptide 分子名称: GLYCEROL, Histone H4, NAD-dependent protein deacylase, ... 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXJ	Crystal structure of CobB wt in complex with H4K16-Acetyl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXP	Crystal structure of CobB Ac2 (A76G,I131C,V162A) in complex with H4K16-Crotonyl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXL	Crystal structure of CobB wt in complex with H4K16-Crotonyl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXR	Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16Cr-2'OH-ADPr peptide intermediate after co-crystallisation 分子名称: Histone H4, NAD-dependent protein deacylase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{S})-4-[(~{E})-but-2-enoxy]-3,5-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6RXO	Crystal structure of CobB Ac2 (A76G, I131C, V162A) in complex with H4K16-Buturyl peptide 分子名称: Histone H4, NAD-dependent protein deacylase, ZINC ION 著者 Spinck, M, Gasper, R, Neumann, H. 登録日 2019-06-08 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Evolved, Selective Erasers of Distinct Lysine Acylations. Angew.Chem.Int.Ed.Engl., 59, 2020
6L65	Sirtuin 2 protein with H3K18 myristoylated peptide 分子名称: MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ... 著者 Chen, L.F. 登録日 2019-10-28 公開日 2020-11-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
6LJM	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P13 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-SER-LEU-GLY-SLL, NAD-dependent protein deacylase sirtuin-5, ... 著者 Chen, Q, Yu, Y. 登録日 2019-12-17 公開日 2020-10-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192, 2020
6L66	Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule 分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PRO-ARG-LYS-GLN-LEU-ALA, ... 著者 Chen, L.F. 登録日 2019-10-28 公開日 2020-11-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.169 Å) 主引用文献 Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
6LJN	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P15 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-HIS-PHE-SER-SLL, NAD-dependent protein deacylase sirtuin-5, ... 著者 Chen, Q, Yu, Y. 登録日 2019-12-17 公開日 2020-10-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192, 2020
6LJK	Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF 分子名称: BE2-SER-ALA-ILE-LYS-SER-NIY-GLY-SET, GLUTARIC ACID, NAD-dependent protein deacylase sirtuin-5, ... 著者 Chen, Q, Yu, Y. 登録日 2019-12-17 公開日 2020-12-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.394 Å) 主引用文献 Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192, 2020
6L72	Sirtuin 2 demyristoylation native final product 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate 著者 Chen, L.F. 登録日 2019-10-30 公開日 2021-03-31 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
6L71	Sirtuin 2 demyristoylation native intermediate I & II mixture 分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE, PRO-ARG-LYS-GLN-LEU-ALA, ... 著者 Chen, L.F. 登録日 2019-10-30 公開日 2021-03-31 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.109 Å) 主引用文献 Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
6NR0	SIRT2(56-356) with covalent intermediate between mechanism-based inhibitor Glucose-TM-1beta and 1'-SH ADP-ribose 分子名称: GLYCEROL, NAD-dependent protein deacetylase sirtuin-2, N~2~-[3-(2-hydroxyethoxy)propanoyl]-N-phenyl-N~6~-tetradecanethioyl-L-lysinamide, ... 著者 Price, I.R, Hong, J. 登録日 2019-01-22 公開日 2020-01-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors. Acs Chem.Biol., 14, 2019
4UTN	Crystal structure of zebrafish Sirtuin 5 in complex with succinylated CPS1-peptide 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... 著者 Pannek, M, Gertz, M, Steegborn, C. 登録日 2014-07-21 公開日 2014-08-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53, 2014
4UU7	Crystal structure of zebrafish Sirtuin 5 in complex with 3-methyl- succinylated CPS1-peptide 分子名称: (2R)-2-methylbutanedioic acid, (2S)-2-methylbutanedioic acid, 1,2-ETHANEDIOL, ... 著者 Pannek, M, Gertz, M, Steegborn, C. 登録日 2014-07-24 公開日 2014-08-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53, 2014
4UTZ	Crystal structure of zebrafish Sirtuin 5 in complex with adipoylated CPS1-peptide 分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBAMOYLPHOSPHATE SYNTHETASE I, ... 著者 Pannek, M, Gertz, M, Steegborn, C. 登録日 2014-07-24 公開日 2014-08-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Chemical Probing of the Human Sirtuin 5 Active Site Reveals its Substrate Acyl Specificity and Peptide-Based Inhibitors. Angew.Chem.Int.Ed.Engl., 53, 2014

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