PDB: 226 件ウェブページステータス検索Chemie searchBIRD

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2NYR	Crystal Structure of Human Sirtuin Homolog 5 in Complex with Suramin 分子名称: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, NAD-dependent deacetylase sirtuin-5, ZINC ION 著者 Min, J.R, Antoshenko, T, Allali-Hassani, A, Dong, A, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-11-21 公開日 2006-12-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. Structure, 15, 2007
2OD2	Crystal Structure of yHst2 I117F mutant bound to carba-NAD+ and an acetylated H4 peptide 分子名称: Acetylated H4 peptide, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... 著者 Sanders, B.D. 登録日 2006-12-21 公開日 2007-02-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
6FLG	Crystal structure of zebrafish Sirtuin 5 in complex with 3(S)-(naphthylthio)succinyl-CPS1 peptide 分子名称: 1,2-ETHANEDIOL, 3(S)-(naphthylthio)succinyl-CPS1 peptide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Pannek, M, Steegborn, C. 登録日 2018-01-25 公開日 2018-04-18 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Potent and Selective Inhibitors of Human Sirtuin 5. J. Med. Chem., 61, 2018
1M2G	Sir2 homologue-ADP ribose complex 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION 著者 Chang, J, Cho, Y. 登録日 2002-06-24 公開日 2003-04-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for the NAD-dependent deacetylase mechanism of Sir2 J.BIOL.CHEM., 277, 2002
2OD9	Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes 分子名称: 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, H4 peptide, NAD-dependent deacetylase HST2, ... 著者 Marmorstein, R, Sanders, B.D. 登録日 2006-12-21 公開日 2007-02-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
1M2J	Sir2 homologue H80N mutant-ADP ribose complex 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION 著者 Chang, J, Cho, Y. 登録日 2002-06-24 公開日 2003-04-08 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for the NAD-dependent deacetylase mechanism of Sir2 J.BIOL.CHEM., 277, 2002
2OD7	Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide 分子名称: 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Acetylated histone H4 peptide, NAD-dependent deacetylase HST2, ... 著者 Marmorstein, R.Q, Sanders, B.D. 登録日 2006-12-21 公開日 2007-02-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
6FKY	Crystal structure of zebrafish Sirtuin 5 in complex with 3-(benzylthio)succinyl-CPS1 peptide 分子名称: (2~{R})-2-(phenylmethylsulfanyl)butanedioic acid, (2~{S})-2-(phenylmethylsulfanyl)butanedioic acid, 1,2-ETHANEDIOL, ... 著者 Pannek, M, Steegborn, C. 登録日 2018-01-25 公開日 2018-03-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.98 Å) 主引用文献 Potent and Selective Inhibitors of Human Sirtuin 5. J. Med. Chem., 61, 2018
1M2H	Sir2 homologue S24A mutant-ADP ribose complex 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION 著者 Chang, J, Cho, Y. 登録日 2002-06-24 公開日 2003-04-08 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the NAD-dependent deacetylase mechanism of Sir2 J.BIOL.CHEM., 277, 2002
1MA3	Structure of a Sir2 enzyme bound to an acetylated p53 peptide 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cellular tumor antigen p53, Transcriptional regulatory protein, ... 著者 Avalos, J.L, Celic, I, Muhammad, S, Cosgrove, M.S, Boeke, J.D, Wolberger, C. 登録日 2002-07-31 公開日 2002-10-16 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of a Sir2 enzyme bound to an acetylated p53 peptide Mol.Cell, 10, 2002
1M2N	Sir2 homologues (D102G/F159A/R170A) mutant-2'-O-acetyl ADP ribose complex 分子名称: 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION 著者 Chang, J, Cho, Y. 登録日 2002-06-24 公開日 2003-04-08 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for the NAD-dependent deacetylase mechanism of Sir2 J.BIOL.CHEM., 277, 2003
6FKZ	Crystal structure of zebrafish Sirtuin 5 in complex with 3-(phenylthio)succinyl-CPS1 peptide 分子名称: 3(R)-(phenylthio)succinyl-CPS1 peptide, 3(S)-(phenylthio)succinyl-CPS1 peptide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Pannek, M, Steegborn, C. 登録日 2018-01-25 公開日 2018-05-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Potent and Selective Inhibitors of Human Sirtuin 5. J. Med. Chem., 61, 2018
2QQF	Hst2 bound to ADP-HPD and Acetylated histone H4 分子名称: 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... 著者 Marmorstein, R, Sanders, B.D, Zhao, K, Slama, J. 登録日 2007-07-26 公開日 2007-10-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
2QQG	Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide 分子名称: 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... 著者 Marmorstein, R, Sanders, B, Zhao, K, Slama, J. 登録日 2007-07-26 公開日 2007-10-09 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
2H4J	Sir2-deacetylated peptide (from enzymatic turnover in crystal) 分子名称: 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, NAD-dependent deacetylase, ... 著者 Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. 登録日 2006-05-24 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
2H2D	The Structural Basis for Sirtuin Substrate Affinity 分子名称: Cellular tumor antigen p53 peptide, NAD-dependent deacetylase, ZINC ION 著者 Cosgrove, M.S, Wolberger, C. 登録日 2006-05-18 公開日 2006-09-19 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 On the Structural Basis of Sirtuin Substrate Affinity Biochemistry, 45, 2006
2H2F	The Structural basis for Sirtuin Substrate affinity 分子名称: Cellular tumor antigen p53, NAD-dependent deacetylase, ZINC ION 著者 Cosgrove, M.S, Wolberger, C. 登録日 2006-05-18 公開日 2006-12-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structural basis of sirtuin substrate affinity Biochemistry, 45, 2006
2H59	Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose 分子名称: (2S,3S,4R,5S)-2-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-4,5-DIHYDROXYTETRAHYDROFURAN-3-YL ACETATE, ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, ... 著者 Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. 登録日 2006-05-25 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
2H2I	The Structural basis of Sirtuin Substrate Affinity 分子名称: (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL, NAD-dependent deacetylase, ZINC ION 著者 Cosgrove, M.S, Wolberger, C. 登録日 2006-05-18 公開日 2006-12-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The structural basis of sirtuin substrate affinity Biochemistry, 45, 2006
2H4F	Sir2-p53 peptide-NAD+ 分子名称: Cellular tumor antigen p53, NAD-dependent deacetylase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. 登録日 2006-05-24 公開日 2006-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14, 2006
6L65	Sirtuin 2 protein with H3K18 myristoylated peptide 分子名称: MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ... 著者 Chen, L.F. 登録日 2019-10-28 公開日 2020-11-04 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
6LJM	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P13 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-SER-LEU-GLY-SLL, NAD-dependent protein deacylase sirtuin-5, ... 著者 Chen, Q, Yu, Y. 登録日 2019-12-17 公開日 2020-10-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192, 2020
6L66	Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule 分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PRO-ARG-LYS-GLN-LEU-ALA, ... 著者 Chen, L.F. 登録日 2019-10-28 公開日 2020-11-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.169 Å) 主引用文献 Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
6LJN	Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P15 分子名称: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-HIS-PHE-SER-SLL, NAD-dependent protein deacylase sirtuin-5, ... 著者 Chen, Q, Yu, Y. 登録日 2019-12-17 公開日 2020-10-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192, 2020
4Y6Q	Human SIRT2 in complex with 2-O-myristoyl-ADP-ribose 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate 著者 Kudo, N, Ito, A, Yoshida, M. 登録日 2015-02-13 公開日 2016-01-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation. Biochemistry, 54, 2015

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