2H4J

Sir2-deacetylated peptide (from enzymatic turnover in crystal)

Summary for 2H4J

• Entry DOI: 10.2210/pdb2h4j/pdb
• Related: 2H4F 2H4H
• Descriptor: NAD-dependent deacetylase, Cellular tumor antigen p53, ZINC ION, ... (6 entities in total)
• Functional Keywords: rossmann fold, zn binding domain, hydrolase
• Biological source: Thermotoga maritima; More
• Cellular location: Cytoplasm : Q9WYW0; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 2
• Total formula weight: 30457.17

Authors

Hoff, K.G.,Avalos, J.L.,Sens, K.,Wolberger, C. (deposition date: 2006-05-24, release date: 2006-09-05, Last modification date: 2023-08-30)

• Primary citation: Hoff, K.G.,Avalos, J.L.,Sens, K.,Wolberger, C.; Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide.; Structure, 14:1231-1240, 2006; PubMed: 16905097; DOI: 10.1016/j.str.2006.06.006

Experimental method

X-RAY DIFFRACTION (2.1 Å)