2H4H
Sir2 H116Y mutant-p53 peptide-NAD
Summary for 2H4H
Entry DOI | 10.2210/pdb2h4h/pdb |
Related | 2H4F |
Descriptor | NAD-dependent deacetylase, Cellular tumor antigen p53, ZINC ION, ... (5 entities in total) |
Functional Keywords | rossmann fold, zn-binding domain, hydrolase |
Biological source | Thermotoga maritima More |
Cellular location | Cytoplasm (Probable): Q9WYW0 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: Q9NP68 |
Total number of polymer chains | 2 |
Total formula weight | 30463.17 |
Authors | Hoff, K.G.,Avalos, J.L.,Sens, K.,Wolberger, C. (deposition date: 2006-05-24, release date: 2006-09-05, Last modification date: 2023-11-15) |
Primary citation | Hoff, K.G.,Avalos, J.L.,Sens, K.,Wolberger, C. Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide. Structure, 14:1231-1240, 2006 Cited by PubMed: 16905097DOI: 10.1016/j.str.2006.06.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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