2H4H
Sir2 H116Y mutant-p53 peptide-NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NAD-dependent deacetylase | polymer | 246 | 27594.8 | 1 | UniProt (Q9WYW0) Pfam (PF02146) In PDB | Thermotoga maritima | Regulatory protein SIR2 homolog |
| 2 | B | Cellular tumor antigen p53 | polymer | 18 | 2139.5 | 1 | UniProt (Q9NP68) UniProt (by SIFTS) (P04637) In PDB | Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13 | |
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 5 | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 1 - 246 (UniProt: Q9WYW0)
B: 1 - 18 (UniProt: Q9NP68)
| PDB | External Database | Details |
|---|---|---|
| Tyr 116 | His 116 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Aly 11 | Lys 382 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29734.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 728.8 | |
| All* | Total formula weight | 30463.2 |
