2QQG

Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide

Summary for 2QQG

• Entry DOI: 10.2210/pdb2qqg/pdb
• Related: 2OD9
• Descriptor: NAD-dependent deacetylase HST2, Histone H4, ZINC ION, ... (6 entities in total)
• Functional Keywords: hst2, sir2, histone deacetylase, hydrolase, metal-binding, nad, nucleus, repressor, transcription, transcription regulation, zinc
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Cellular location: Cytoplasm: P53686; Nucleus: P02309
• Total number of polymer chains: 2
• Total formula weight: 36835.31

Authors

Marmorstein, R.,Sanders, B.,Zhao, K.,Slama, J. (deposition date: 2007-07-26, release date: 2007-10-09, Last modification date: 2023-11-15)

• Primary citation: Sanders, B.D.,Zhao, K.,Slama, J.T.,Marmorstein, R.; Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes.; Mol.Cell, 25:463-472, 2007; PubMed: 17289592; DOI: 10.1016/j.molcel.2006.12.022

Experimental method

X-RAY DIFFRACTION (2.05 Å)