2QQG

Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	NAD-dependent deacetylase HST2	polymer	308	34794.8	1	UniProt (P53686) Pfam (PF02146)	Saccharomyces cerevisiae (baker's yeast)	Homologous to SIR2 protein 2
2	B (B)	Histone H4	polymer	11	1310.6	1	UniProt (P02309)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE	non-polymer		542.3	1	Chemie (A1R)
5	E (A)	NICOTINAMIDE	non-polymer		122.1	1	Chemie (NCA)
6	F, G (A, B)	water	water		18.0	116	Chemie (HOH)

Sequence modifications

A: 1 - 294 (UniProt: P53686)

PDB	External Database	Details
Met -13	-	expression tag
Arg -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36105.4
Non-Polymers*	Number of molecules	3
	Total formula weight	729.9
All*	Total formula weight	36835.3

*Water molecules are not included.