Sir2 homologues (D102G/F159A/R170A) mutant-2'-O-acetyl ADP ribose complex

Summary for 1M2N

Related1M2G 1M2H 1M2J 1M2K
DescriptorSilent Information Regulator 2, ZINC ION, 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, ... (4 entities in total)
Functional Keywordsprotein-ligand complex, gene regulation
Biological sourceArchaeoglobus fulgidus
Cellular locationCytoplasm (Probable) O28597
Total number of polymer chains2
Total molecular weight56195.05
Chang, J.,Cho, Y. (deposition date: 2002-06-24, release date: 2003-04-08, Last modification date: 2011-07-13)
Primary citation
Chang, J.H.,Kim, H.C.,Hwang, K.Y.,Lee, J.W.,Jackson, S.P.,Bell, S.D.,Cho, Y.
Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277:34489-34498, 2003
PubMed: 12091395 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M205460200
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers28 1.6% 6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23