1M2N
Sir2 homologues (D102G/F159A/R170A) mutant-2'-O-acetyl ADP ribose complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Silent Information Regulator 2 | polymer | 249 | 27430.8 | 2 | UniProt (O28597) Pfam (PF02146) | Archaeoglobus fulgidus | transcriptional regulatory protein, Sir2 family |
| 2 | C, D (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | E, F (B) | 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE | non-polymer | 601.4 | 2 | Chemie (OAD) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 245 (UniProt: O28597)
| PDB | External Database | Details |
|---|---|---|
| Gly 102 | Asp 102 | engineered mutation |
| Ala 159 | Phe 159 | engineered mutation |
| Ala 170 | Arg 170 | engineered mutation |
| Leu 246 | - | cloning artifact |
| Lys 247 | - | cloning artifact |
| Leu 248 | - | cloning artifact |
| Asn 249 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54861.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1333.5 | |
| All* | Total formula weight | 56195.0 |
