6FLG

Crystal structure of zebrafish Sirtuin 5 in complex with 3(S)-(naphthylthio)succinyl-CPS1 peptide

Summary for 6FLG

Entry DOI	10.2210/pdb6flg/pdb
Descriptor	NAD-dependent protein deacylase sirtuin-5, mitochondrial, 3(S)-(naphthylthio)succinyl-CPS1 peptide, ZINC ION, ... (7 entities in total)
Functional Keywords	sirtuin 5, inhibitor, deacylase, signaling protein
Biological source	Danio rerio (Zebrafish) More
Cellular location	Mitochondrion : Q6DHI5
Total number of polymer chains	3
Total formula weight	64833.88
Authors	Pannek, M.,Steegborn, C. (deposition date: 2018-01-25, release date: 2018-04-18, Last modification date: 2024-01-17)
Primary citation	Kalbas, D.,Liebscher, S.,Nowak, T.,Meleshin, M.,Pannek, M.,Popp, C.,Alhalabi, Z.,Bordusa, F.,Sippl, W.,Steegborn, C.,Schutkowski, M. Potent and Selective Inhibitors of Human Sirtuin 5. J. Med. Chem., 61:2460-2471, 2018 Cited by PubMed: 29494161 DOI: 10.1021/acs.jmedchem.7b01648 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation