6FLG
Crystal structure of zebrafish Sirtuin 5 in complex with 3(S)-(naphthylthio)succinyl-CPS1 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000035 | molecular_function | acyl binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006476 | biological_process | protein deacetylation |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0010566 | biological_process | regulation of ketone biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0036047 | biological_process | peptidyl-lysine demalonylation |
| A | 0036048 | biological_process | protein desuccinylation |
| A | 0036049 | biological_process | peptidyl-lysine desuccinylation |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061697 | molecular_function | protein-glutaryllysine deglutarylase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| A | 1901363 | molecular_function | heterocyclic compound binding |
| B | 0000035 | molecular_function | acyl binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0006476 | biological_process | protein deacetylation |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0010566 | biological_process | regulation of ketone biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| B | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| B | 0036047 | biological_process | peptidyl-lysine demalonylation |
| B | 0036048 | biological_process | protein desuccinylation |
| B | 0036049 | biological_process | peptidyl-lysine desuccinylation |
| B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061697 | molecular_function | protein-glutaryllysine deglutarylase activity |
| B | 0070403 | molecular_function | NAD+ binding |
| B | 1901363 | molecular_function | heterocyclic compound binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS162 |
| A | CYS165 |
| A | CYS203 |
| A | CYS208 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | ILE176 |
| A | ARG202 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 401 |
| Chain | Residue |
| A | ALA145 |
| B | ARG144 |
| B | ALA145 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue EPE B 402 |
| Chain | Residue |
| A | THR229 |
| A | GLU232 |
| B | ALA78 |
| B | ALA82 |
| B | TYR98 |
| B | ARG101 |
| B | HIS154 |
| B | VAL217 |
| B | TRP218 |
| B | PHE219 |
| B | TYR251 |
| B | EDO405 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| B | CYS162 |
| B | CYS165 |
| B | CYS203 |
| B | CYS208 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | HIS99 |
| B | GLU103 |
| B | GLY182 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | GLN136 |
| B | ASN137 |
| B | EPE402 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide GZB C 1 and VAL C 2 |
| Chain | Residue |
| A | THR222 |
| A | LEU223 |
| A | LEU228 |
| B | LEU228 |
| B | GLU232 |
| B | MET255 |
| B | GLN259 |
| C | LEU3 |
| C | DQK4 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide LEU C 3 and DQK C 4 |
| Chain | Residue |
| A | THR65 |
| A | TYR98 |
| A | ARG101 |
| A | GLN136 |
| A | ASN137 |
| A | ILE138 |
| A | HIS154 |
| A | VAL217 |
| A | PHE219 |
| A | GLU221 |
| A | TYR251 |
| B | GLN259 |
| C | GZB1 |
| C | VAL2 |
| C | GLU5 |
| C | TYR6 |
| C | GLY7 |
| site_id | AD1 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide DQK C 4 and GLU C 5 |
| Chain | Residue |
| A | THR65 |
| A | TYR98 |
| A | ARG101 |
| A | GLN136 |
| A | ASN137 |
| A | ILE138 |
| A | HIS154 |
| A | VAL217 |
| A | PHE219 |
| A | GLU221 |
| A | TYR251 |
| C | VAL2 |
| C | LEU3 |
| C | TYR6 |
| C | GLY7 |
| C | VAL8 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
| Chain | Residue | Details |
| A | HIS154 | |
| B | HIS154 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
| Chain | Residue | Details |
| A | GLY54 | |
| A | ASN271 | |
| A | CYS289 | |
| B | GLY54 | |
| B | TYR98 | |
| B | ARG101 | |
| B | GLN136 | |
| B | CYS162 | |
| B | CYS165 | |
| B | CYS203 | |
| B | CYS208 | |
| A | TYR98 | |
| B | GLY245 | |
| B | ASN271 | |
| B | CYS289 | |
| A | ARG101 | |
| A | GLN136 | |
| A | CYS162 | |
| A | CYS165 | |
| A | CYS203 | |
| A | CYS208 | |
| A | GLY245 |
