6LJM
Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P13
Summary for 6LJM
Entry DOI | 10.2210/pdb6ljm/pdb |
Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, ACE-SER-LEU-GLY-SLL, ZINC ION, ... (5 entities in total) |
Functional Keywords | sirt5, inhibitor, hydrolase, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 30338.85 |
Authors | |
Primary citation | Yang, L.L.,Wang, H.L.,Yan, Y.H.,Liu, S.,Yu, Z.J.,Huang, M.Y.,Luo, Y.,Zheng, X.,Yu, Y.,Li, G.B. Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery. Eur.J.Med.Chem., 192:112201-112201, 2020 Cited by PubMed: 32163813DOI: 10.1016/j.ejmech.2020.112201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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