6FKZ
Crystal structure of zebrafish Sirtuin 5 in complex with 3-(phenylthio)succinyl-CPS1 peptide
Summary for 6FKZ
| Entry DOI | 10.2210/pdb6fkz/pdb |
| Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, 3(S)-(phenylthio)succinyl-CPS1 peptide, 3(R)-(phenylthio)succinyl-CPS1 peptide, ... (7 entities in total) |
| Functional Keywords | sirtuin 5, inhibitor, deacylase, signaling protein |
| Biological source | Danio rerio (Zebrafish) More |
| Cellular location | Mitochondrion : Q6DHI5 |
| Total number of polymer chains | 4 |
| Total formula weight | 65837.98 |
| Authors | Pannek, M.,Steegborn, C. (deposition date: 2018-01-25, release date: 2018-05-16, Last modification date: 2024-01-17) |
| Primary citation | Kalbas, D.,Liebscher, S.,Nowak, T.,Meleshin, M.,Pannek, M.,Popp, C.,Alhalabi, Z.,Bordusa, F.,Sippl, W.,Steegborn, C.,Schutkowski, M. Potent and Selective Inhibitors of Human Sirtuin 5. J. Med. Chem., 61:2460-2471, 2018 Cited by PubMed: 29494161DOI: 10.1021/acs.jmedchem.7b01648 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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