4Y6Q
Human SIRT2 in complex with 2-O-myristoyl-ADP-ribose
Summary for 4Y6Q
Entry DOI | 10.2210/pdb4y6q/pdb |
Related | 4Y6L 4Y6O |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate, ... (4 entities in total) |
Functional Keywords | sirtuin, sirt, nad-dependent deacetylase, 2-o-myristoyl-adp-ribose, acyl-adp-ribose, complex, deacylase, intermediate, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 136145.21 |
Authors | Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2015-02-13, release date: 2016-01-06, Last modification date: 2023-11-08) |
Primary citation | Feldman, J.L.,Dittenhafer-Reed, K.E.,Kudo, N.,Thelen, J.N.,Ito, A.,Yoshida, M.,Denu, J.M. Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation. Biochemistry, 54:3037-3050, 2015 Cited by PubMed: 25897714DOI: 10.1021/acs.biochem.5b00150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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