4Y6L

Human SIRT2 in complex with myristoylated peptide (H3K9myr)

Summary for 4Y6L

• Entry DOI: 10.2210/pdb4y6l/pdb
• Related: 4Y6O 4Y6Q
• Descriptor: NAD-dependent protein deacetylase sirtuin-2, peptide THR-ALA-ARG-MYK-SER-THR-GLY, ZINC ION, ... (4 entities in total)
• Functional Keywords: sirtuin, sirt, nad-dependent deacetylase, myristoylated lysine, hydrolase-peptide complex, hydrolase/peptide
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 68395.57

Authors

Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2015-02-13, release date: 2016-01-06, Last modification date: 2023-11-08)

• Primary citation: Feldman, J.L.,Dittenhafer-Reed, K.E.,Kudo, N.,Thelen, J.N.,Ito, A.,Yoshida, M.,Denu, J.M.; Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.; Biochemistry, 54:3037-3050, 2015; PubMed: 25897714; DOI: 10.1021/acs.biochem.5b00150

Experimental method

X-RAY DIFFRACTION (1.6 Å)