4Y6L
Human SIRT2 in complex with myristoylated peptide (H3K9myr)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS195 |
| B | CYS200 |
| B | CYS221 |
| B | CYS224 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide ARG C 8 and MYK C 9 |
| Chain | Residue |
| A | PHE119 |
| A | GLU137 |
| A | PHE143 |
| A | HIS187 |
| A | PHE190 |
| A | VAL233 |
| A | PHE235 |
| A | GLY236 |
| A | GLU237 |
| A | SER238 |
| A | GLN267 |
| C | THR6 |
| C | ALA7 |
| C | SER10 |
| C | HOH103 |
| C | HOH105 |
| C | HOH110 |
| A | PHE96 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide MYK C 9 and SER C 10 |
| Chain | Residue |
| A | PHE96 |
| A | PHE119 |
| A | PHE143 |
| A | HIS187 |
| A | PHE190 |
| A | VAL233 |
| A | PHE235 |
| A | GLY236 |
| A | GLU237 |
| A | VAL266 |
| A | GLN267 |
| C | ARG8 |
| C | THR11 |
| C | GLY12 |
| C | HOH103 |
| C | HOH105 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide ARG D 8 and MYK D 9 |
| Chain | Residue |
| B | PHE96 |
| B | PHE143 |
| B | HIS187 |
| B | VAL233 |
| B | PHE235 |
| B | GLY236 |
| B | GLU237 |
| B | GLN267 |
| D | THR6 |
| D | ALA7 |
| D | SER10 |
| D | HOH103 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide MYK D 9 and SER D 10 |
| Chain | Residue |
| B | PHE96 |
| B | PHE143 |
| B | HIS187 |
| B | VAL233 |
| B | PHE235 |
| B | GLY236 |
| B | GLU237 |
| B | VAL266 |
| B | GLN267 |
| D | ARG8 |
| D | THR11 |
| D | GLY12 |
| D | HOH103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| C | THR6 | |
| D | THR6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| C | ARG8 | |
| B | THR262 | |
| B | ASN286 | |
| B | GLY336 | |
| D | ARG8 | |
| A | GLN167 | |
| A | THR262 | |
| A | ASN286 | |
| A | GLY336 | |
| B | ALA85 | |
| B | ASP95 | |
| B | GLN167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| C | MYK9 | |
| D | MYK9 | |
| A | CYS221 | |
| A | CYS224 | |
| B | CYS195 | |
| B | CYS200 | |
| B | CYS221 | |
| B | CYS224 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| C | SER10 | |
| D | SER10 | |
| A | SER207 | |
| B | SER53 | |
| B | SER100 | |
| B | SER207 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| C | THR11 | |
| D | THR11 |
