PDB: 438 件ウェブページステータス検索Chemie searchBIRD

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2WRX	Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0 分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION 著者 Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. 登録日 2009-09-02 公開日 2010-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
3T2A	TMAO-grown cubic insulin (porcine) 分子名称: Insulin A chain, Insulin B chain, trimethylamine oxide 著者 Cahn, J, Venkat, M, Marshall, H, Juers, D. 登録日 2011-07-22 公開日 2011-12-28 最終更新日 2012-01-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The use of trimethylamine N-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography. Acta Crystallogr.,Sect.D, 68, 2012
1KMF	NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES 分子名称: Insulin 著者 Xu, B, Hua, Q.X, Nakagawa, S.H, Jia, W, Chu, Y.C, Katsoyannis, P.G, Weiss, M.A. 登録日 2001-12-14 公開日 2002-01-09 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue. J.Mol.Biol., 316, 2002
3V1G	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health 分子名称: CHLORIDE ION, Insulin, PHENOL, ... 著者 Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. 登録日 2011-12-09 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published
1LKQ	NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES 分子名称: INSULIN 著者 Weiss, M.A, Hua, Q.X, Chu, Y.C, Jia, W, Philips, N.F, Wang, R.Y, Katsoyannis, P.G. 登録日 2002-04-25 公開日 2002-05-22 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing J.Biol.Chem., 277, 2002
8RVT	Structure of full-length human insulin fibrils 分子名称: Insulin A chain, Insulin B chain 著者 Bardiaux, B, Suladze, S, Reif, B. 登録日 2024-02-02 公開日 2024-05-29 最終更新日 2024-06-12 実験手法 SOLID-STATE NMR 主引用文献 Atomic resolution structure of full-length human insulin fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
8PI4	Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in dimer (T2) conformation 分子名称: Insulin B chain,Insulin A chain 著者 Johansson, E, Schluckebier, G. 登録日 2023-06-21 公開日 2023-11-08 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PJH	Crystal structure of human insulin desB30 precursor with an Aspartate-Glycine-Lysine C-peptide in dimer (T2) conformation 分子名称: Insulin 著者 Schluckebier, G, Johansson, E. 登録日 2023-06-23 公開日 2023-11-08 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PI5	Crystal structure of human insulin desB30 precursor with an Alanine-Methionine-Lysine C-peptide in hexamer (T3R3) conformation 分子名称: CHLORIDE ION, Insulin B chain,Insulin A chain, RESORCINOL, ... 著者 Johansson, E, Schluckebier, G. 登録日 2023-06-21 公開日 2023-11-08 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PI6	Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension 分子名称: Insulin B chain,Insulin A chain 著者 Johansson, E, Schluckebier, G. 登録日 2023-06-21 公開日 2023-11-08 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8PJC	Crystal structure of human insulin desB30 precursor with an Alanine-Alanine-Lysine C-peptide in dimer (T2) conformation 分子名称: Insulin 著者 Schluckebier, G, Johansson, E. 登録日 2023-06-23 公開日 2023-11-08 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Molecular engineering of insulin for recombinant expression in yeast. Trends Biotechnol, 42, 2024
8RRP	Insulin Icodec - A14E B16H B25H B29Ne-C20 diacid-LgGlu-2xAdo desB30 human insulin 分子名称: ACETATE ION, Insulin, Insulin B chain 著者 Schluckebier, G, Johansson, E. 登録日 2024-01-23 公開日 2024-07-10 最終更新日 2024-07-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec. Nat Commun, 15, 2024
1MSO	T6 Human Insulin at 1.0 A Resolution 分子名称: Insulin A-Chain, Insulin B-Chain, ZINC ION 著者 Smith, G.D, Pangborn, W.A, Blessing, R.H. 登録日 2002-09-19 公開日 2003-03-04 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 The structure of T6 human insulin at 1.0 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
2WS6	Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form 分子名称: CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... 著者 Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. 登録日 2009-09-03 公開日 2010-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
3V19	Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health 分子名称: CHLORIDE ION, Insulin, PHENOL, ... 著者 Wan, Z.L, Hua, Q.X, Wickramasinghe, N.P, Huang, K, Petkova, A.T, Hu, S.Q, Phillips, N.B, Yeh, I.J, Whittake, J, Ismail-Beigi, F, Katsoyyannis, P.G, Tycko, R, Weiss, M.A. 登録日 2011-12-09 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health To be Published
1MPJ	X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL 分子名称: CHLORIDE ION, PHENOL, PHENOL INSULIN, ... 著者 Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. 登録日 1995-09-13 公開日 1996-01-29 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry, 34, 1995
2ZPP	Neutron crystal structure of cubic insulin at pD9 分子名称: Insulin A chain, Insulin B chain 著者 Ishikawa, T, Tanaka, I, Niimura, N. 登録日 2008-07-26 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 NEUTRON DIFFRACTION (2.5 Å) 主引用文献 An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis Biochem.Biophys.Res.Commun., 376, 2008
2ZP6	Crystal structure of Bovine Insulin (Hexameric form) 分子名称: Insulin A chain, Insulin B chain, ZINC ION 著者 Jaimohan, S.M, Naresh, M.D, Mandal, A.B. 登録日 2008-06-27 公開日 2008-07-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Crystal structure of Bovine Insulin (Hexameric form) To be Published
3U4N	A novel covalently linked insulin dimer 分子名称: Insulin A chain, Insulin B chain 著者 Norrman, M, Vinther, T.N. 登録日 2011-10-10 公開日 2012-04-11 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization. Plos One, 7, 2012
3W80	Crystal structure of dodecamer human insulin with double C-axis length of the hexamer 2 Zn insulin cell 分子名称: Insulin, ZINC ION 著者 Murayoshi, M, Sasaki, K, Sakabe, N, Sakabe, K. 登録日 2013-03-11 公開日 2013-07-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of dodecamer insulin with double C-axis length of the hexamer 2 Zn insulin celll To be Published
3W7Y	0.92A structure of 2Zn human insulin at 100K 分子名称: Insulin, ZINC ION 著者 Sakabe, N, Sakabe, K, Sasaki, K, Murayoshi, M. 登録日 2013-03-11 公開日 2013-07-03 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (0.92 Å) 主引用文献 0.92A structure of 2Zn human insulin at 100K To be Published
3TT8	Crystal Structure Analysis of Cu Human Insulin Derivative 分子名称: COPPER (II) ION, INSULIN A-CHAIN, INSULIN B-CHAIN 著者 Prugovecki, B, Matkovic-Calogovic, D. 登録日 2011-09-14 公開日 2011-10-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Crystal Structure Analysis of Cu Human Insulin Derivative To be Published
4IDW	Polycrystalline T6 Bovine Insulin: Anisotropic Lattice Evolution and Novel Structure Refinement Strategy 分子名称: Insulin A chain, Insulin B chain, ZINC ION 著者 Margiolaki, I, Giannopoulou, A.E, Wright, J.P, Knight, L, Norrman, M, Schluckebier, G, Fitch, A, Von Dreele, R.B. 登録日 2012-12-13 公開日 2013-06-05 実験手法 POWDER DIFFRACTION 主引用文献 High-resolution powder X-ray data reveal the T6 hexameric form of bovine insulin Acta Crystallogr.,Sect.D, 69, 2013
4IYD	Insulin glargine crystal structure 1 分子名称: Insulin A chain, Insulin B chain 著者 Barba de la Rosa, A.P, Lara-Gonzalez, S, Montero-Moran, G.M, Escobedo-Moratilla, A. 登録日 2013-01-28 公開日 2014-02-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Physicochemical and structural analysis of a biosimilar insulin glargine formulation and its reference to be published
4IUZ	High resolution crystal structure of racemic ester insulin 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ... 著者 Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H. 登録日 2013-01-22 公開日 2013-02-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography. J.Am.Chem.Soc., 135, 2013

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