PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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5TIL	Murine class I major histocompatibility complex H-2 Db in complex with LCMV-derived GP33 altered peptide V3P and T-cell receptor P14 分子名称: Alpha chain of murine P14 T cell receptor, Beta chain of murine T cell receptor P14, Beta-2-microglobulin, ... 著者 Achour, A, Sandalova, T, Allerbring, E.B. 登録日 2016-10-03 公開日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Ternary complexes of TCR P14 give insights into the mechanisms behind reestablishment of CTL responses against a viral escape mutant To be published
5TMZ	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S,17S)-16-(3-methoxybenzyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 分子名称: (9beta,13alpha,14beta,16alpha,17alpha)-16-[(4-methoxyphenyl)methyl]estra-1,3,5(10)-triene-3,17-diol, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-13 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.207 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5TN7	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with (E)-3'-fluoro-4'-hydroxy-3-((hydroxyiminio)methyl)-[1,1'-biphenyl]-4-olate 分子名称: 3-fluoro-3'-[(E)-(hydroxyimino)methyl][1,1'-biphenyl]-4,4'-diol, Estrogen receptor, Nuclear receptor coactivator 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Minutolo, F, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-13 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.238 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
3K7I	Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain 分子名称: Indian hedgehog protein, SULFATE ION, ZINC ION 著者 He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. 登録日 2009-10-13 公開日 2011-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.438 Å) 主引用文献 Crystal structure of the E131K mutant of the Indian Hedgehog N-terminal signalling domain To be Published
5JOZ	Bacteroides ovatus Xyloglucan PUL GH43B 分子名称: CALCIUM ION, Non-reducing end alpha-L-arabinofuranosidase BoGH43B 著者 Hemsworth, G.R, Thompson, A.J, Stepper, J, Sobala, L.F, Coyle, T, Larsbrink, J, Spadiut, O, Stubbs, K.A, Brumer, H, Davies, G.J. 登録日 2016-05-03 公開日 2016-08-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut. Open Biology, 6, 2016
5V9P	Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A 分子名称: Lysine-specific demethylase 5A, NICKEL (II) ION, SULFATE ION, ... 著者 Kiefer, J.R, Liang, J, Vinogradova, M. 登録日 2017-03-23 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
5JSN	Bcl2-inhibitor complex 分子名称: Apoptosis regulator Bcl-2, Bcl2 inhibitor 著者 Shen, B.W, Stoddard, B.L. 登録日 2016-05-09 公開日 2016-11-16 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
5VAM	BRAF in Complex with RAF709 分子名称: N-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide, Serine/threonine-protein kinase B-raf 著者 Mamo, M, Appleton, B.A. 登録日 2017-03-27 公開日 2017-06-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers. J. Med. Chem., 60, 2017
1R6G	Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound 分子名称: 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL, Thyroid hormone receptor beta-1 著者 Hangeland, J.J, Dejneka, T, Friends, T.J, Devasthale, P, Mellstrom, K, Sandberg, J, Grynfarb, M, Doweyko, A.M, Sack, J.S, Einspahr, H, Farnegardh, M, Husman, B, Ljunggren, J, Koehler, K, Sheppard, C, Malm, J, Ryono, D.E. 登録日 2003-10-15 公開日 2005-02-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta. Bioorg.Med.Chem.Lett., 14, 2004
1R15	Aplysia ADP ribosyl cyclase with bound nicotinamide and R5P 分子名称: ADP-ribosyl cyclase, ANY 5'-MONOPHOSPHATE NUCLEOTIDE, NICOTINAMIDE 著者 Love, M.L, Szebenyi, D.M.E, Kriksunov, I.A, Thiel, D.J, Munshi, C, Graeff, R, Lee, H.C, Hao, Q. 登録日 2003-09-23 公開日 2004-03-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure, 12, 2004
5UIO	structure of DHFR with bound DAP, p-ABG and NADP 分子名称: BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FORMIC ACID, ... 著者 Pedersen, L.C, London, R.E. 登録日 2017-01-14 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5JWD	Crystal structure of H-2Db in complex with the LCMV-derived GP392-401 peptide 分子名称: Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... 著者 Buratto, J, Badia-Martinez, D, Norstrom, M, Sandalova, T, Achour, A. 登録日 2016-05-12 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity. PLoS ONE, 12, 2017
1R54	Crystal structure of the catalytic domain of human ADAM33 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADAM 33, CALCIUM ION, ... 著者 Orth, P, Reicher, P, Wang, W, Prosise, W.W, Yarosh-Tomaine, T, Hammond, G, Xiao, L, Mirza, U.A, Zou, J, Strickland, C, Taremi, S.S. 登録日 2003-10-09 公開日 2004-10-12 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structre of the catalytic domain of human ADAM33 J.Mol.Biol., 335, 2004
1BDA	CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE) 分子名称: N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl) butyl]glycinamide, SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR 著者 Bode, W, Renatus, M, Engh, R.A. 登録日 1998-05-07 公開日 1999-05-11 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. EMBO J., 16, 1997
3K7H	Crystal structure of the E95K mutant of the Indian Hedgehog N-terminal signalling domain 分子名称: Indian hedgehog protein, SULFATE ION, ZINC ION 著者 He, Y.-X, Kang, Y, Zhang, W.J, Yu, J, Ma, G, Zhou, C.-Z. 登録日 2009-10-13 公開日 2011-01-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of the E95K mutant of the Indian Hedgehog N-terminal signalling domain To be Published
5V9J	Crystal structure of catalytic domain of GLP with MS0105 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase EHMT1, ... 著者 Dong, A, Zeng, H, Liu, J, Xiong, Y, Babault, N, Jin, J, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Wu, H, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2017-03-23 公開日 2018-03-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Crystal structure of catalytic domain of GLP with MS0105 to be published
5ULK	Crystal Structure of RNF165 in complex with a UbcH5b~Ub conjugate 分子名称: E3 ubiquitin-protein ligase RNF165, Ubiquitin, Ubiquitin-conjugating enzyme E2 D2, ... 著者 Middleton, A.J, Day, C.L, Wright, J.D. 登録日 2017-01-24 公開日 2017-06-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Discovery of new non-covalent ubiquitin binding sites on UbcH5 To be published
5VAX	Bcl-2 complex with Beclin 1 BH3 domain 分子名称: Apoptosis regulator Bcl-2 -- Bcl-2-like protein 1 Chimera, Beclin-1 著者 Lee, E.F, Smith, B.J, Yao, S, Fairlie, W.D. 登録日 2017-03-28 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Bcl-2 complex with Beclin 1 pT108 BH3 domain To Be Published
1B3I	NMR SOLUTION STRUCTURE OF PLASTOCYANIN FROM THE PHOTOSYNTHETIC PROKARYOTE, PROCHLOROTHRIX HOLLANDICA (MINIMIZED AVERAGE STRUCTURE) 分子名称: COPPER (I) ION, PROTEIN (PLASTOCYANIN) 著者 Babu, C.R, Volkman, B.F, Bullerjahn, G.S. 登録日 1998-12-11 公開日 1999-04-27 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of plastocyanin from the photosynthetic prokaryote, Prochlorothrix hollandica. Biochemistry, 38, 1999
4X3P	Sirt2 in complex with a myristoyl peptide 分子名称: 1,2-ETHANEDIOL, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NAD-dependent protein deacetylase sirtuin-2, ... 著者 Wang, Y, Zhang, W, Hao, Q. 登録日 2014-12-01 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell Chem Biol, 24, 2017
1RFO	Trimeric Foldon of the T4 phagehead fibritin 分子名称: whisker antigen control protein 著者 Guthe, S, Kapinos, L, Moglich, A, Meier, S, Kiefhaber, T, Grzesiek, S. 登録日 2003-11-10 公開日 2004-03-30 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Very fast folding and association of a trimerization domain from bacteriophage t4 fibritin. J.Mol.Biol., 337, 2004
1AQL	CRYSTAL STRUCTURE OF BOVINE BILE-SALT ACTIVATED LIPASE COMPLEXED WITH TAUROCHOLATE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BILE-SALT ACTIVATED LIPASE, TAUROCHOLIC ACID 著者 Wang, X, Zhang, X. 登録日 1997-07-30 公開日 1998-08-05 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of bovine bile salt activated lipase: insights into the bile salt activation mechanism. Structure, 5, 1997
1RU5	Solution structure of porcine peptide YY (pPYY) 分子名称: Peptide YY 著者 Lerch, M, Mayrhofer, M, Zerbe, O. 登録日 2003-12-11 公開日 2004-06-08 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors. J.Mol.Biol., 339, 2004
1R5A	Glutathione S-transferase 分子名称: COPPER (II) ION, GLUTATHIONE SULFONIC ACID, glutathione transferase 著者 Oakley, A.J. 登録日 2003-10-09 公開日 2003-10-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification, characterization and structure of a new Delta class glutathione transferase isoenzyme. Biochem.J., 388, 2005
3K05	The crystal structure of MDC1 BRCT T2067D in complex with a minimal recognition tetrapeptide with an amidated C-terminus 分子名称: GLYCEROL, Mediator of DNA damage checkpoint protein 1, phospho peptide 著者 Campbell, S.J, Edwards, R.A, Glover, J.N. 登録日 2009-09-24 公開日 2010-03-02 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1 Structure, 18, 2010

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