5UIO

structure of DHFR with bound DAP, p-ABG and NADP

Summary for 5UIO

• Entry DOI: 10.2210/pdb5uio/pdb
• Related: 5UIH 5UII 5UIP
• Descriptor: Dihydrofolate reductase, PYRIMIDINE-2,4-DIAMINE, N-(4-aminobenzene-1-carbonyl)-L-glutamic acid, ... (7 entities in total)
• Functional Keywords: dhfr, nadp, 2, 4 diaminopyridine, n-(4aminobenzoyl)-l-glutamate, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 5
• Total formula weight: 101031.91

Authors

Pedersen, L.C.,London, R.E. (deposition date: 2017-01-14, release date: 2017-11-22, Last modification date: 2023-10-04)

• Primary citation: Gabel, S.A.,Duff, M.R.,Pedersen, L.C.,DeRose, E.F.,Krahn, J.M.,Howell, E.E.,London, R.E.; A Structural Basis for Biguanide Activity.; Biochemistry, 56:4786-4798, 2017; PubMed: 28766937; DOI: 10.1021/acs.biochem.7b00619

Experimental method

X-RAY DIFFRACTION (1.929 Å)