5UIO
structure of DHFR with bound DAP, p-ABG and NADP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | Dihydrofolate reductase | polymer | 170 | 19207.6 | 5 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | |
2 | A, B, C, D, E | PYRIMIDINE-2,4-DIAMINE | non-polymer | 110.1 | 5 | Chemie (LG3) | |||
3 | A, C, D, E | N-(4-aminobenzene-1-carbonyl)-L-glutamic acid | non-polymer | 266.3 | 4 | Chemie (8DM) | |||
4 | A, C, D, E | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
5 | B, C, D, E | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 4 | Chemie (BME) | |||
6 | B, C | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
7 | water | water | 18.0 | 616 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 159 (UniProt: P0ABQ4)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Gly 160 | - | expression tag |
Gly 161 | - | expression tag |
Gly 162 | - | expression tag |
Gly 163 | - | expression tag |
His 164 | - | expression tag |
His 165 | - | expression tag |
His 166 | - | expression tag |
His 167 | - | expression tag |
His 168 | - | expression tag |
His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 96038.1 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 4993.8 | |
All* | Total formula weight | 101031.9 |