5VAM

BRAF in Complex with RAF709

Summary for 5VAM

• Entry DOI: 10.2210/pdb5vam/pdb
• Related: 5VAL
• Descriptor: Serine/threonine-protein kinase B-raf, N-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide (3 entities in total)
• Functional Keywords: braf serine/threonine-protein kinase b-raf, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 64912.86

Authors

Mamo, M.,Appleton, B.A. (deposition date: 2017-03-27, release date: 2017-06-28, Last modification date: 2024-03-06)

• Primary citation: Nishiguchi, G.A.,Rico, A.,Tanner, H.,Aversa, R.J.,Taft, B.R.,Subramanian, S.,Setti, L.,Burger, M.T.,Wan, L.,Tamez, V.,Smith, A.,Lou, Y.,Barsanti, P.A.,Appleton, B.A.,Mamo, M.,Tandeske, L.,Dix, I.,Tellew, J.E.,Huang, S.,Mathews Griner, L.A.,Cooke, V.G.,Van Abbema, A.,Merritt, H.,Ma, S.,Gampa, K.,Feng, F.,Yuan, J.,Wang, Y.,Haling, J.R.,Vaziri, S.,Hekmat-Nejad, M.,Jansen, J.M.,Polyakov, V.,Zang, R.,Sethuraman, V.,Amiri, P.,Singh, M.,Lees, E.,Shao, W.,Stuart, D.D.,Dillon, M.P.,Ramurthy, S.; Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.; J. Med. Chem., 60:4869-4881, 2017; PubMed: 28557458; DOI: 10.1021/acs.jmedchem.6b01862

Experimental method

X-RAY DIFFRACTION (2.1 Å)