4X3P
Sirt2 in complex with a myristoyl peptide
Summary for 4X3P
Entry DOI | 10.2210/pdb4x3p/pdb |
Related | 4X3O |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, peptide PRO-LYS-LYS-THR-GLY, ZINC ION, ... (7 entities in total) |
Functional Keywords | sirt2, myristoyl peptide, hydrolase-peptide complex, hydrolase/peptide |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6 |
Total number of polymer chains | 2 |
Total formula weight | 35940.68 |
Authors | |
Primary citation | Wang, Y.,Fung, Y.M.E.,Zhang, W.,He, B.,Chung, M.W.H.,Jin, J.,Hu, J.,Lin, H.,Hao, Q. Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell Chem Biol, 24:339-345, 2017 Cited by PubMed: 28286128DOI: 10.1016/j.chembiol.2017.02.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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