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1R6G

Crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound

Summary for 1R6G
Entry DOI10.2210/pdb1r6g/pdb
DescriptorThyroid hormone receptor beta-1, 2-[3,5-DIBROMO-4-(4-HYDROXY-3-{HYDROXY[(2-PHENYLETHYL)AMINO]METHYL}PHENOXY)PHENYL]ETHANE-1,1-DIOL (2 entities in total)
Functional Keywordsalpha helical, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P10828
Total number of polymer chains1
Total formula weight29826.16
Authors
Primary citationHangeland, J.J.,Doweyko, A.M.,Dejneka, T.,Friends, T.J.,Devasthale, P.,Mellstrom, K.,Sandberg, J.,Grynfarb, M.,Sack, J.S.,Einspahr, H.,Farnegardh, M.,Husman, B.,Ljunggren, J.,Koehler, K.,Sheppard, C.,Malm, J.,Ryono, D.E.
Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta.
Bioorg.Med.Chem.Lett., 14:3549-3553, 2004
Cited by
PubMed: 15177471
DOI: 10.1016/j.bmcl.2004.04.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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