5JSN
Bcl2-inhibitor complex
Summary for 5JSN
Entry DOI | 10.2210/pdb5jsn/pdb |
Related | 4OYD 5JSB |
Descriptor | Apoptosis regulator Bcl-2, Bcl2 inhibitor (3 entities in total) |
Functional Keywords | bcl-2, antibcl2, complex, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Mitochondrion outer membrane ; Single-pass membrane protein : P10415 |
Total number of polymer chains | 4 |
Total formula weight | 75575.60 |
Authors | Shen, B.W.,Stoddard, B.L. (deposition date: 2016-05-09, release date: 2016-11-16, Last modification date: 2024-03-06) |
Primary citation | Berger, S.,Procko, E.,Margineantu, D.,Lee, E.F.,Shen, B.W.,Zelter, A.,Silva, D.A.,Chawla, K.,Herold, M.J.,Garnier, J.M.,Johnson, R.,MacCoss, M.J.,Lessene, G.,Davis, T.N.,Stayton, P.S.,Stoddard, B.L.,Fairlie, W.D.,Hockenbery, D.M.,Baker, D. Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5:-, 2016 Cited by PubMed: 27805565DOI: 10.7554/eLife.20352 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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