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8GG9
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CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8GGR
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Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #10 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8JSO
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AMPH-bound hTAAR1-Gs protein complex
分子名称: (2S)-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
登録日2023-06-20
公開日2023-11-15
最終更新日2024-01-03
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
7XK9
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BU of 7xk9 by Molmil
Structure of human beta2 adrenergic receptor bound to constrained isoproterenol
分子名称: (5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ...
著者Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P.
登録日2022-04-19
公開日2023-04-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.
Nat Commun, 14, 2023
6WGT
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BU of 6wgt by Molmil
Crystal structure of HTR2A with hallucinogenic agonist
分子名称: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ...
著者Kim, K.L, Che, T, Krumm, B.E, Roth, B.L.
登録日2020-04-06
公開日2020-09-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
6WH4
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Crystal structure of HTR2A with inverse agonist
分子名称: 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 fusion, CHOLESTEROL, ...
著者Kim, K.L, Che, T, Krumm, B.E, Roth, B.L.
登録日2020-04-07
公開日2020-09-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor
Cell(Cambridge,Mass.), 182, 2020
7C6A
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BU of 7c6a by Molmil
Crystal structure of AT2R-BRIL and SRP2070_Fab complex
分子名称: IgG Light Chain, IgG heavy chain, SAR1, ...
著者Suzuki, M, Miyagi, H, Asada, H, Yasunaga, M, Suno, C, Takahashi, Y, Saito, J, Iwata, S.
登録日2020-05-21
公開日2020-07-29
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
7W7E
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BU of 7w7e by Molmil
Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist
分子名称: 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Xu, J, Fink, E.A, Shoichet, B.K, Du, Y.
登録日2021-12-04
公開日2022-09-28
最終更新日2022-10-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor.
Science, 377, 2022
7V69
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BU of 7v69 by Molmil
Cryo-EM structure of a class A GPCR-G protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T.
登録日2021-08-20
公開日2022-05-11
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
7V68
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An Agonist and PAM-bound Class A GPCR with Gi protein complex structure
分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, J.J, Wu, L.J, Wu, M, Hua, T, Liu, Z.J, Wang, T.
登録日2021-08-20
公開日2022-05-11
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
8GGU
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Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #13 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-08
公開日2024-03-06
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8EJK
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BU of 8ejk by Molmil
Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc
分子名称: A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M.
登録日2022-09-17
公開日2023-05-24
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
8GE1
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BU of 8ge1 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#2 of 20)
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Papasergi-Scott, M.M, Skiniotis, G.
登録日2023-03-06
公開日2024-03-06
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
4DAJ
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BU of 4daj by Molmil
Structure of the M3 Muscarinic Acetylcholine Receptor
分子名称: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, Muscarinic acetylcholine receptor M3, Lysozyme, ...
著者Kruse, A.C, Hu, J, Pan, A.C, Arlow, D.H, Rosenbaum, D.M, Rosemond, E, Green, H.F, Liu, T, Chae, P.S, Dror, R.O, Shaw, D.E, Weis, W.I, Wess, J, Kobilka, B.
登録日2012-01-12
公開日2012-02-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Nature, 482, 2012
8DPI
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BU of 8dpi by Molmil
Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin
分子名称: (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ...
著者Gumpper, R.H, Fay, J.F, Roth, B.L.
登録日2022-07-15
公開日2022-08-24
最終更新日2022-08-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors.
Cell Rep, 40, 2022
3C9M
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BU of 3c9m by Molmil
Structure of a mutant bovine rhodopsin in hexagonal crystal form
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYL GROUP, RETINAL, ...
著者Stenkamp, R.E.
登録日2008-02-16
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Alternative models for two crystal structures of bovine rhodopsin.
Acta Crystallogr.,Sect.D, 64, 2008
5G53
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BU of 5g53 by Molmil
Structure of the adenosine A2A receptor bound to an engineered G protein
分子名称: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ...
著者Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G.
登録日2016-05-19
公開日2016-08-03
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016
7XBX
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BU of 7xbx by Molmil
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q.
登録日2022-03-22
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
3KJ6
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BU of 3kj6 by Molmil
Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex
分子名称: Beta-2 adrenergic receptor, Fab heavy chain, Fab light chain, ...
著者Bokoch, M.P, Zou, Y, Rasmussen, S.G.F, Liu, C.W, Nygaard, R, Rosenbaum, D.M, Fung, J.J, Choi, H.-J, Thian, F.S, Kobilka, T.S, Puglisi, J.D, Weis, W.I, Pardo, L, Prosser, S, Mueller, L, Kobilka, B.K.
登録日2009-11-02
公開日2010-02-16
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Nature, 463, 2010
6LFO
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BU of 6lfo by Molmil
Cryo-EM structure of a class A GPCR monomer
分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J.
登録日2019-12-03
公開日2020-09-02
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis of CXC chemokine receptor 2 activation and signalling.
Nature, 585, 2020
7YU3
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Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Akasaka, H, Shihoya, W, Nureki, O.
登録日2022-08-16
公開日2022-10-05
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist.
Nat Commun, 13, 2022
2R4S
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BU of 2r4s by Molmil
Crystal structure of the human beta2 adrenoceptor
分子名称: Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ...
著者Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K.
登録日2007-08-31
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
2R4R
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BU of 2r4r by Molmil
Crystal structure of the human beta2 adrenoceptor
分子名称: Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ...
著者Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K.
登録日2007-08-31
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Nature, 450, 2007
8IC0
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BU of 8ic0 by Molmil
Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer
分子名称: C-X-C chemokine receptor type 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Ishimoto, N, Park, J.H, Park, S.Y.
登録日2023-02-10
公開日2023-07-19
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Structural basis of CXC chemokine receptor 1 ligand binding and activation.
Nat Commun, 14, 2023
7EW0
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Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
分子名称: 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yuan, Y, Jia, G.W, Su, Z.M, Shao, Z.H.
登録日2021-05-24
公開日2021-09-29
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.
Cell Res., 31, 2021

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件を2024-07-17に公開中

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