PDB: 142 件ウェブページステータス検索Chemie searchBIRD

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3B4V	X-Ray structure of Activin in complex with FSTL3 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Inhibin beta A chain, ... 著者 Thompson, T.B. 登録日 2007-10-24 公開日 2008-09-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity. J.Biol.Chem., 283, 2008
3KFD	Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 分子名称: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-1 著者 Radaev, S, Sun, P.D. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.995 Å) 主引用文献 Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily. J.Biol.Chem., 285, 2010
3EO1	Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 分子名称: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, Transforming growth factor beta-3 著者 Gruetter, C, Gruetter, M.G. 登録日 2008-09-26 公開日 2008-12-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions Proc.Natl.Acad.Sci.Usa, 105, 2008
3QB4	Crystal structure of a TGF-beta ligand-receptor complex 分子名称: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5 著者 Mueller, T.D, Nickel, J, Sebald, W. 登録日 2011-01-12 公開日 2012-03-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 GDF-5 can act as a context-dependent BMP-2 antagonist. Bmc Biol., 13, 2015
2V5E	The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding. 分子名称: 1,2-ETHANEDIOL, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Parkash, V, Leppanen, V.-M, Virtanen, H, Jurvansuu, J.-M, Bespalov, M.M, Sidorova, Y.A, Runeberg-Roos, P, Saarma, M, Goldman, A. 登録日 2008-10-03 公開日 2008-10-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding. J.Biol.Chem., 283, 2008
3SEK	Crystal Structure of the Myostatin:Follistatin-like 3 Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8 著者 Cash, J.N, Thompson, T.B. 登録日 2011-06-10 公開日 2011-11-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. J.Biol.Chem., 287, 2012
1NYU	Crystal Structure of Activin A Bound to the ECD of ActRIIB 分子名称: Inhibin beta A chain, activin receptor 著者 Thompson, T.B, Woodruff, T.K, Jardetzky, T.S. 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions EMBO J., 22, 2003
1NYS	Crystal Structure of Activin A Bound to the ECD of ActRIIB P41 分子名称: Inhibin beta A chain, activin receptor 著者 Thompson, T.B, Woodruff, T.K, Jardetzky, T.S. 登録日 2003-02-13 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions EMBO J., 22, 2003
3FUB	Crystal structure of GDNF-GFRalpha1 complex 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Parkash, V, Goldman, A. 登録日 2009-01-14 公開日 2009-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling Acta Crystallogr.,Sect.F, 65, 2009
3EVS	Crystal structure of the GDF-5:BMP receptor IB complex. 分子名称: Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 著者 Kotzsch, A, Mueller, T.D. 登録日 2008-10-13 公開日 2009-03-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. Embo J., 28, 2009
1REW	Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor 分子名称: bone morphogenetic protein 2, bone morphogenetic protein receptor type IA 著者 Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. 登録日 2003-11-07 公開日 2004-05-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.863 Å) 主引用文献 Molecular recognition of BMP-2 and BMP receptor IA. Nat.Struct.Mol.Biol., 11, 2004
3RJR	Crystal Structure of pro-TGF beta 1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1 著者 Zhu, J.H, Shi, M.L, Springer, T.A. 登録日 2011-04-15 公開日 2011-06-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Latent TGF-Beta structure and activation Nature, 474, 2011
1ES7	COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS 分子名称: BONE MORPHOGENETIC PROTEIN RECEPTOR IA, BONE MORPHOGENETIC PROTEIN-2 著者 Kirsch, T, Sebald, W, Dreyer, M.K. 登録日 2000-04-07 公開日 2000-10-07 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the BMP-2-BRIA ectodomain complex. Nat.Struct.Biol., 7, 2000
2QJB	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION 著者 Kotzsch, A, Mueller, T.D. 登録日 2007-07-06 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
2QJA	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Kotzsch, A, Mueller, T.D. 登録日 2007-07-06 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
6Z3M	Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and Neogenin 1 (NEO1). 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 5, Neogenin, ... 著者 Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (5.501 Å) 主引用文献 Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117, 2020
7AML	RET/GDNF/GFRa1 extracellular complex Cryo-EM structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ... 著者 Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q. 登録日 2020-10-09 公開日 2021-01-13 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29, 2021
7AB8	Crystal structure of a GDNF-GFRalpha1 complex 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ... 著者 Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q. 登録日 2020-09-07 公開日 2021-01-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29, 2021
7AG0	Complex between the bone morphogenetic protein 2 and its antagonist Noggin 分子名称: Bone morphogenetic protein 2, GLYCEROL, Noggin 著者 Robert, C, Bruck, F, Herman, R, Vandevenne, M, Filee, P, Kerff, F, Matagne, A. 登録日 2020-09-21 公開日 2022-04-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.104 Å) 主引用文献 Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. J.Biol.Chem., 299, 2023
2P6A	The structure of the Activin:Follistatin 315 complex 分子名称: Follistatin, Inhibin beta A chain, probable fragment of follistatin 著者 Lerch, T.F, Shimasaki, S, Woodruff, T.K, Jardetzky, T.S. 登録日 2007-03-16 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. J.Biol.Chem., 282, 2007
2PJY	Structural basis for cooperative assembly of the TGF-beta signaling complex 分子名称: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-3 著者 Groppe, J, Zubieta, C. 登録日 2007-04-16 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol.Cell, 29, 2008
2QJ9	Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1 分子名称: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Kotzsch, A, Mueller, T.D. 登録日 2007-07-06 公開日 2008-01-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J.Biol.Chem., 283, 2008
6SF2	Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain and extracellular domain of activin receptor-like kinase 1 (ALK1). 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Serine/threonine-protein kinase receptor R3 著者 Salmon, R.M, Guo, J, Yu, M, Li, W. 登録日 2019-07-31 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms. Nat Commun, 11, 2020
5HZW	Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Growth/differentiation factor 2, Maltose-binding periplasmic protein,Endoglin, ... 著者 Bokhove, M, Saito, T, Jovine, L. 登録日 2016-02-03 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (4.451 Å) 主引用文献 Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep, 19, 2017
4UI1	Crystal structure of the human RGMC-BMP2 complex 分子名称: 1,2-ETHANEDIOL, BONE MORPHOGENETIC PROTEIN 2, CHLORIDE ION, ... 著者 Healey, E.G, Bishop, B, Elegheert, J, Bell, C.H, Padilla-Parra, S, Siebold, C. 登録日 2015-03-27 公開日 2015-05-06 最終更新日 2015-06-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Repulsive Guidance Molecule is a Structural Bridge between Neogenin and Bone Morphogenetic Protein. Nat.Struct.Mol.Biol., 22, 2015

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