The structure of the Activin:Follistatin 315 complex

Summary for 2P6A

DescriptorInhibin beta A chain, Follistatin, probable fragment of follistatin (3 entities in total)
Functional Keywordsfollistatin, activin, inhibin, tgf-beta, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted P08476 P19883
Total number of polymer chains5
Total molecular weight96305.28
Lerch, T.F.,Shimasaki, S.,Woodruff, T.K.,Jardetzky, T.S. (deposition date: 2007-03-16, release date: 2007-04-03, Last modification date: 2011-11-09)
Primary citation
Lerch, T.F.,Shimasaki, S.,Woodruff, T.K.,Jardetzky, T.S.
Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions.
J.Biol.Chem., 282:15930-15939, 2007
PubMed: 17409095 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M700737200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.326104 13.1% 22.0% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02