2P6A

The structure of the Activin:Follistatin 315 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008083	molecular_function	growth factor activity
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0030154	biological_process	cell differentiation
C	0030510	biological_process	regulation of BMP signaling pathway
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0038102	molecular_function	activin receptor antagonist activity
C	0043395	molecular_function	heparan sulfate proteoglycan binding
C	0048185	molecular_function	activin binding
C	0051798	biological_process	positive regulation of hair follicle development
C	0071363	biological_process	cellular response to growth factor stimulus
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0002244	biological_process	hematopoietic progenitor cell differentiation
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0030154	biological_process	cell differentiation
D	0030510	biological_process	regulation of BMP signaling pathway
D	0032926	biological_process	negative regulation of activin receptor signaling pathway
D	0038102	molecular_function	activin receptor antagonist activity
D	0043395	molecular_function	heparan sulfate proteoglycan binding
D	0048185	molecular_function	activin binding
D	0051798	biological_process	positive regulation of hair follicle development
D	0071363	biological_process	cellular response to growth factor stimulus

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IiaPsgYhanyCeGeC

Chain	Residue	Details
A	ILE29-CYS44

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	Domain: {"description":"Follistatin-like 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	55
Details	Domain: {"description":"Kazal-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00798","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	48
Details	Domain: {"description":"Follistatin-like 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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