PDB: 1374 件ウェブページステータス検索Chemie searchBIRD

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6OB3	Crystal structure of G13D-KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GTPase KRas, ... 著者 Tran, T.H, Dharmaiah, S, Simanshu, D.K. 登録日 2019-03-19 公開日 2019-10-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 116, 2019
6OIM	Crystal Structure of human KRAS G12C covalently bound to AMG 510 分子名称: AMG 510 (bound form), GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-04-09 公開日 2019-11-06 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature, 575, 2019
6OQ3	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2 分子名称: 2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2019-04-25 公開日 2020-06-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells Faseb Bioadv, 2021
6OQ4	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1 分子名称: 2-{(Z)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-[(1S)-1-phenylethyl]benzamide, Krev interaction trapped protein 1, MAGNESIUM ION, ... 著者 Gingras, A.R. 登録日 2019-04-25 公開日 2020-06-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.754 Å) 主引用文献 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells Faseb Bioadv, 2021
6P0I	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 1,2-ETHANEDIOL, 4-[(5-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid, ACETATE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0J	Crystal structure of GDP-bound human RalA 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Ral-A 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0K	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(6-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0L	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(2-methoxypyridin-3-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0M	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(3-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0N	Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds. 分子名称: 4-[(6-fluoropyridin-2-yl)sulfamoyl]benzene-1-sulfonic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0O	Crystal structure of GDP-bound human RalA 分子名称: CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Ral-A 著者 Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Ghozayel, M.K, Xu, D, Meroueh, S.O. 登録日 2019-05-17 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117, 2020
6P0Z	Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg 分子名称: ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... 著者 Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. 登録日 2019-05-17 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.011 Å) 主引用文献 Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
6P8W	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. 分子名称: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-06-08 公開日 2019-08-28 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
6P8X	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. 分子名称: 2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ... 著者 Mohr, C. 登録日 2019-06-08 公開日 2019-08-28 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
6P8Y	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. 分子名称: 2-[5-bromo-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-06-08 公開日 2019-08-28 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
6P8Z	Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor 分子名称: 2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-7-methyl-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ... 著者 Mohr, C. 登録日 2019-06-08 公開日 2019-08-28 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
6PGO	Crystal structure of human KRAS G12C covalently bound to a phthalazine inhibitor 分子名称: 1-{4-[7-chloro-6-(2-fluoro-6-hydroxyphenyl)-4-phenylphthalazin-1-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Mohr, C. 登録日 2019-06-24 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. J.Med.Chem., 63, 2020
6PGP	Crystal structure of human KRAS G12C covalently bound to a quinazolinone inhibitor 分子名称: 6-chloro-7-(2-fluoro-6-hydroxyphenyl)-4-(4-propanoylpiperazin-1-yl)-1-[2-(propan-2-yl)phenyl]quinazolin-2(1H)-one, CALCIUM ION, GTPase KRas, ... 著者 Mohr, C, Whittington, D.A. 登録日 2019-06-24 公開日 2019-12-25 最終更新日 2020-01-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. J.Med.Chem., 63, 2020
6PQ3	Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Dharmaiah, S, Chan, A.H, Tran, T.H, Simanshu, D.K. 登録日 2019-07-08 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J.Biol.Chem., 295, 2020
6PTS	NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state A) 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... 著者 Fang, Z, Lee, K, Gasmi-Seabrook, G, Ikura, M, Marshall, C.B. 登録日 2019-07-16 公開日 2020-05-13 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane. Proc.Natl.Acad.Sci.USA, 117, 2020
6PTW	NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state B) 分子名称: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... 著者 Fang, Z, Lee, K, Gasmi-Seabrook, G, Ikura, M, Marshall, C.B. 登録日 2019-07-16 公開日 2020-05-13 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane. Proc.Natl.Acad.Sci.USA, 117, 2020
6Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Kim, S.-H. 登録日 1992-07-27 公開日 1992-07-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
6Q82	Crystal structure of the biportin Pdr6 in complex with RanGTP 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin beta-like protein KAP122, ... 著者 Aksu, M, Vera-Rodriguez, A, Trakhanov, S, Gorlich, D. 登録日 2018-12-14 公開日 2019-05-01 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.994 Å) 主引用文献 Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
6Q84	Crystal structure of RanGTP-Pdr6-eIF5A export complex 分子名称: Eukaryotic translation initiation factor 5A-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Aksu, M, Trakhanov, S, Vera-Rodriguez, A, Gorlich, D. 登録日 2018-12-14 公開日 2019-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
6QUU	Crystal Structure of KRAS-G12D in complex with GMP-PCP 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.477 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019

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