6OIM

Crystal Structure of human KRAS G12C covalently bound to AMG 510

Summary for 6OIM

• Entry DOI: 10.2210/pdb6oim/pdb
• Descriptor: GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: inhibitor, gtpase, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 22068.73

Authors

Mohr, C. (deposition date: 2019-04-09, release date: 2019-11-06, Last modification date: 2019-12-18)

• Primary citation: Canon, J.,Rex, K.,Saiki, A.Y.,Mohr, C.,Cooke, K.,Bagal, D.,Gaida, K.,Holt, T.,Knutson, C.G.,Koppada, N.,Lanman, B.A.,Werner, J.,Rapaport, A.S.,San Miguel, T.,Ortiz, R.,Osgood, T.,Sun, J.R.,Zhu, X.,McCarter, J.D.,Volak, L.P.,Houk, B.E.,Fakih, M.G.,O'Neil, B.H.,Price, T.J.,Falchook, G.S.,Desai, J.,Kuo, J.,Govindan, R.,Hong, D.S.,Ouyang, W.,Henary, H.,Arvedson, T.,Cee, V.J.,Lipford, J.R.; The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.; Nature, 575:217-223, 2019; PubMed: 31666701; DOI: 10.1038/s41586-019-1694-1

Experimental method

X-RAY DIFFRACTION (1.65 Å)