6OIM
Crystal Structure of human KRAS G12C covalently bound to AMG 510
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTPase KRas | polymer | 183 | 21038.6 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
4 | A | AMG 510 (bound form) | non-polymer | 562.6 | 1 | Chemie (MOV) | |||
5 | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: P01116)
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
Lys -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
Asp -4 | - | expression tag |
Glu -3 | - | expression tag |
Val -2 | - | expression tag |
Asp -1 | - | expression tag |
Gly 0 | - | expression tag |
Cys 12 | Gly 12 | variant |
Ser 51 | Cys 51 | engineered mutation |
Leu 80 | Cys 80 | engineered mutation |
Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 21038.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1030.1 | |
All* | Total formula weight | 22068.7 |