6P0I
Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds.
Summary for 6P0I
| Entry DOI | 10.2210/pdb6p0i/pdb |
| Descriptor | Ras-related protein Ral-A, GUANOSINE-5'-DIPHOSPHATE, 1,2-ETHANEDIOL, ... (10 entities in total) |
| Functional Keywords | ral gtpase, rala, covalent inhibitor, sulfonyl fluoride, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 22474.05 |
| Authors | Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Liu, D.,Ghozayel, M.K.,Xu, D.,Meroueh, S.O. (deposition date: 2019-05-17, release date: 2020-03-04, Last modification date: 2023-10-11) |
| Primary citation | Bum-Erdene, K.,Liu, D.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Xu, D.,Meroueh, S.O. Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117:7131-7139, 2020 Cited by PubMed: 32179690DOI: 10.1073/pnas.1913654117 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.18 Å) |
Structure validation
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