6P0O

Crystal structure of GDP-bound human RalA

Summary for 6P0O

Entry DOI	10.2210/pdb6p0o/pdb
Descriptor	Ras-related protein Ral-A, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... (4 entities in total)
Functional Keywords	ral gtpase, rala, covalent inhibitor, sulfonyl fluoride, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	21787.13
Authors	Bum-Erdene, K.,Gonzalez-Gutierrez, G.,Liu, D.,Ghozayel, M.K.,Xu, D.,Meroueh, S.O. (deposition date: 2019-05-17, release date: 2020-03-04, Last modification date: 2023-10-11)
Primary citation	Bum-Erdene, K.,Liu, D.,Gonzalez-Gutierrez, G.,Ghozayel, M.K.,Xu, D.,Meroueh, S.O. Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases. Proc.Natl.Acad.Sci.USA, 117:7131-7139, 2020 Cited by PubMed: 32179690 DOI: 10.1073/pnas.1913654117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation