7LD9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ld9 by Molmil](/molmil-images/mine/7ld9) | Structure of human GGT1 in complex with ABBA | 分子名称: | (2R)-2-amino-4-boronobutanoic acid, (2S)-2-amino-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Terzyan, S.S, Hanigan, M. | 登録日 | 2021-01-12 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg.Med.Chem., 73, 2022
|
|
6WZG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wzg by Molmil](/molmil-images/mine/6wzg) | Human secretin receptor Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Piper, S.J, Belousoff, M.J, Danev, R. | 登録日 | 2020-05-13 | 公開日 | 2020-08-12 | 最終更新日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
|
|
7UDS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uds by Molmil](/molmil-images/mine/7uds) | Structure of lineage I (Pinneo) Lassa virus glycoprotein bound to Fab 25.10C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 25.10C Fab Heavy Chain, ... | 著者 | Buck, T.K, Enriquez, A.E, Hastie, K.M. | 登録日 | 2022-03-20 | 公開日 | 2022-06-15 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Neutralizing Antibodies against Lassa Virus Lineage I. Mbio, 13, 2022
|
|
6WW2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ww2 by Molmil](/molmil-images/mine/6ww2) | Structure of human Frizzled5 by fiducial-assisted cryo-EM | 分子名称: | Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | 登録日 | 2020-05-07 | 公開日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife, 9, 2020
|
|
7V3T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v3t by Molmil](/molmil-images/mine/7v3t) | Solution structure of thrombin binding aptamer G-quadruplex bound a self-adaptive small molecule with rotated ligands | 分子名称: | 11,13-bis(fluoranyl)-8-(1-methyl-3-pyridin-2-yl-imidazol-2-yl)-8-(1-methyl-3-pyridin-2-yl-imidazol-2-yl)-7$l^{4}-aza-8$l^{4}-platinatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaene, TBA G4 DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3') | 著者 | Liu, W, Zhu, B.C, Mao, Z.W. | 登録日 | 2021-08-11 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a thrombin binding aptamer complex with a non-planar platinum(ii) compound. Chem Sci, 13, 2022
|
|
6WI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wi9 by Molmil](/molmil-images/mine/6wi9) | Human secretin receptor Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Belousoff, M.J, Khoshouei, M. | 登録日 | 2020-04-09 | 公開日 | 2020-08-12 | 最終更新日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
|
|
7LEN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7len by Molmil](/molmil-images/mine/7len) | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | 登録日 | 2021-01-14 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
|
|
7LFR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lfr by Molmil](/molmil-images/mine/7lfr) | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Proepiregulin, ... | 著者 | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | 登録日 | 2021-01-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
|
|
7LFS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lfs by Molmil](/molmil-images/mine/7lfs) | Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 4 of Epidermal growth factor receptor, ... | 著者 | Hu, C, Leche II, C.A, Stayrook, S.E, Ferguson, K.M, Lemmon, M.A. | 登録日 | 2021-01-18 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602, 2022
|
|
7LB8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lb8 by Molmil](/molmil-images/mine/7lb8) | Structure of a ferrichrome importer FhuCDB from E. coli | 分子名称: | Iron(3+)-hydroxamate import ATP-binding protein FhuC, Iron(3+)-hydroxamate import system permease protein FhuB, Iron(3+)-hydroxamate-binding protein FhuD | 著者 | Hu, W, Zheng, H. | 登録日 | 2021-01-07 | 公開日 | 2021-11-24 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer. Commun Biol, 4, 2021
|
|
7LLL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lll by Molmil](/molmil-images/mine/7lll) | Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein | 分子名称: | Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H. | 登録日 | 2021-02-04 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nat Commun, 13, 2022
|
|
7SNM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7snm by Molmil](/molmil-images/mine/7snm) | |
7UOT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uot by Molmil](/molmil-images/mine/7uot) | Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 37.2D heavy chain (variable domain), ... | 著者 | Li, H, Saphire, E.O. | 登録日 | 2022-04-13 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. Sci Transl Med, 14, 2022
|
|
7UJB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ujb by Molmil](/molmil-images/mine/7ujb) | N-terminal domain deletion variant of Eta | 分子名称: | DEAD/DEAH box RNA helicase | 著者 | Qayyum, M.Z, Murakami, K.S. | 登録日 | 2022-03-30 | 公開日 | 2022-08-10 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4.12 Å) | 主引用文献 | The structure and activities of the archaeal transcription termination factor Eta detail vulnerabilities of the transcription elongation complex. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
6WE0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6we0 by Molmil](/molmil-images/mine/6we0) | Wheat dwarf virus Rep domain complexed with a single-stranded DNA 10-mer comprising the cleavage site | 分子名称: | DNA (5'-D(*TP*AP*AP*TP*AP*TP*TP*AP*CP*C)-3'), MANGANESE (II) ION, Replication-associated protein | 著者 | Tompkins, K, Litzau, L.A, Shi, K, Nelson, A, Evans III, R.L, Gordon, W.R. | 登録日 | 2020-04-01 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering. Nucleic Acids Res., 49, 2021
|
|
7U8W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u8w by Molmil](/molmil-images/mine/7u8w) | hTRAP1 with inhibitors | 分子名称: | Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-fluoro-2H-isoindol-2-yl)methanone | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.706 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
|
|
7U8X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u8x by Molmil](/molmil-images/mine/7u8x) | hTRAP1 with inhibitors | 分子名称: | Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-methoxy-2H-isoindol-2-yl)methanone | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
|
|
7U8V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u8v by Molmil](/molmil-images/mine/7u8v) | hTRAP1 with inhibitors | 分子名称: | (4-hydroxy-1,3-phenylene)bis[(2H-isoindol-2-yl)methanone], Heat shock protein 75 kDa, mitochondrial | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.448 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
|
|
7U8U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u8u by Molmil](/molmil-images/mine/7u8u) | hTRAP1 with inhibitors | 分子名称: | Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone | 著者 | Deng, J, Matts, R, Peng, S. | 登録日 | 2022-03-09 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.065 Å) | 主引用文献 | Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258, 2023
|
|
7LM3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lm3 by Molmil](/molmil-images/mine/7lm3) | |
6VWX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vwx by Molmil](/molmil-images/mine/6vwx) | NaChBac in lipid nanodisc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, BH1501 protein, SODIUM ION | 著者 | Yan, N, Gao, S. | 登録日 | 2020-02-20 | 公開日 | 2020-06-24 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
1GQR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gqr by Molmil](/molmil-images/mine/1gqr) | ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH RIVASTIGMINE | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL, ACETYLCHOLINESTERASE, ... | 著者 | Raves, M.L, Harel, M, Silman, I, Sussman, J.L. | 登録日 | 2001-12-04 | 公開日 | 2002-03-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine Biochemistry, 41, 2002
|
|
7SU1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7su1 by Molmil](/molmil-images/mine/7su1) | Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Fab heavy chain, ... | 著者 | Lee, P.S, Chau, B, Strop, P. | 登録日 | 2021-11-15 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14, 2022
|
|
7T5K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t5k by Molmil](/molmil-images/mine/7t5k) | E. coli dihydroorotate dehydrogenase bound to the inhibitor HQNO | 分子名称: | 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ... | 著者 | Horwitz, S.M, Ambarian, J.A, Davis, K.M. | 登録日 | 2021-12-12 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines. Rsc Chem Biol, 3, 2022
|
|
7T6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7t6h by Molmil](/molmil-images/mine/7t6h) | E. coli dihydroorotate dehydrogenase | 分子名称: | Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, OROTIC ACID | 著者 | Horwitz, S.M, Ambarian, J.A, Davis, K.M. | 登録日 | 2021-12-13 | 公開日 | 2022-03-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines. Rsc Chem Biol, 3, 2022
|
|