7U8W

hTRAP1 with inhibitors

Summary for 7U8W

Entry DOI	10.2210/pdb7u8w/pdb
Descriptor	Heat shock protein 75 kDa, mitochondrial, [5-(4-fluoro-2H-isoindole-2-carbonyl)-2-hydroxyphenyl](5-fluoro-2H-isoindol-2-yl)methanone (3 entities in total)
Functional Keywords	htrap1, inhibitor, chaperone
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	56033.53
Authors	Deng, J.,Matts, R.,Peng, S. (deposition date: 2022-03-09, release date: 2023-08-16)
Primary citation	Merfeld, T.,Peng, S.,Keegan, B.M.,Crowley, V.M.,Brackett, C.M.,Gutierrez, A.,McCann, N.R.,Reynolds, T.S.,Rhodes, M.C.,Byrd, K.M.,Deng, J.,Matts, R.L.,Blagg, B.S.J. Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur.J.Med.Chem., 258:115531-115531, 2023 Cited by PubMed: 37307624 DOI: 10.1016/j.ejmech.2023.115531 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.706 Å)

Structure validation