7V3T

Solution structure of thrombin binding aptamer G-quadruplex bound a self-adaptive small molecule with rotated ligands

Summary for 7V3T

• Entry DOI: 10.2210/pdb7v3t/pdb
• Descriptor: TBA G4 DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'), 11,13-bis(fluoranyl)-8-(1-methyl-3-pyridin-2-yl-imidazol-2-yl)-8-(1-methyl-3-pyridin-2-yl-imidazol-2-yl)-7$l^{4}-aza-8$l^{4}-platinatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaene (2 entities in total)
• Functional Keywords: g-quadruplex, platinum compound, thrombin binding aptamer, dna-ligand complex structure, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 5446.67

Authors

Liu, W.,Zhu, B.C.,Mao, Z.W. (deposition date: 2021-08-11, release date: 2022-09-28, Last modification date: 2022-12-21)

• Primary citation: Zhu, B.C.,He, J.,Xia, X.Y.,Jiang, J.,Liu, W.,Liu, L.Y.,Liang, B.B.,Yao, H.G.,Ke, Z.,Xia, W.,Mao, Z.W.; Solution structure of a thrombin binding aptamer complex with a non-planar platinum(ii) compound.; Chem Sci, 13:8371-8379, 2022; PubMed: 35919711; DOI: 10.1039/d2sc01196d

Experimental method

SOLUTION NMR