7U8U

hTRAP1 with inhibitors

Summary for 7U8U

• Entry DOI: 10.2210/pdb7u8u/pdb
• Descriptor: Heat shock protein 75 kDa, mitochondrial, [2-hydroxy-5-(2H-isoindole-2-carbonyl)phenyl]{5-[3-(triphenyl-lambda~5~-phosphanyl)propoxy]-2H-isoindol-2-yl}methanone (2 entities in total)
• Functional Keywords: htrap1, inhibitor, chaperone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 111803.07

Authors

Deng, J.,Matts, R.,Peng, S. (deposition date: 2022-03-09, release date: 2023-08-16)

• Primary citation: Merfeld, T.,Peng, S.,Keegan, B.M.,Crowley, V.M.,Brackett, C.M.,Gutierrez, A.,McCann, N.R.,Reynolds, T.S.,Rhodes, M.C.,Byrd, K.M.,Deng, J.,Matts, R.L.,Blagg, B.S.J.; Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.; Eur.J.Med.Chem., 258:115531-115531, 2023; PubMed: 37307624; DOI: 10.1016/j.ejmech.2023.115531

Experimental method

X-RAY DIFFRACTION (3.065 Å)